Evaluierung eines qualitativen schnelltestes fur kardiales troponin T zur praklinischen diagnostik bei patienten mit akutem koronarsyndrom

Translated title of the contribution: Preclinical evaluation of a rapid assay for the qualitative detection of cardiac troponin T in EMS patients with acute myocardial ischemia

T. Luiz, K. Ellinger, A. Budde, C. Hechler, H. Klar, T. Riester

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Objective: To evaluate the practical performance and the diagnostic power of a rapid, qualitative assay for the detection of cardiac Troponin T (indicated cut-off level: 0.3 ng/ml) in EMS patients presenting with acute myocardial ischemia. Patients: 145 consecutive patients with non-traumatic chest pain treated by the Mobile Intensive Care Unit team. During phase 1 (73 patients), blood drawn at the emergency site was used to perform a Troponin T rapid assay under defined conditions at the hospital. During phase 2 (72 patients), the rapid assay was already performed at the emergency site. Results: In phase 1 all tests were performed correctly, whereas 5.6 % of the test results had to be declared unvalid in phase 2. 17 (11.7 %) of the 145 patients showed a positive test result. Analytic sensitivity was 100 %, specificity 96.3 %. 37 of the 145 patients (median duration of symptoms: 150 minutes) showed a myocardial infarction (MI). Related to the diagnosis of MI diagnostic sensitivity, specificity, positive and negative predictive values were 35.1, 96.3, 76.5, and 81.3 %. Mortality in patients with a positive rapid assay was 35.3 %, compared to 6.3 % in patients with a negative test result (p < 0.001). Conclusions: The rapid assay allows the detection of Troponin T in concentrations above the cut-off level. Meticulous observance of the manufacturer's rules is imperative. A single preclinical rapid assay does not allow to exclude a MI. However, the test enables EMS personnel to identify patients who are at increased risk of dying from an acute coronary syndrome in the immediate future.

Translated title of the contributionPreclinical evaluation of a rapid assay for the qualitative detection of cardiac troponin T in EMS patients with acute myocardial ischemia
Original languageGerman
Pages (from-to)267-275
Number of pages9
JournalZeitschrift fur Kardiologie
Volume87
Issue number4
DOIs
StatePublished - Jan 1 1998

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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