Abstract
Genetic information in forensic studies is largely limited to CODIS data and the ability to match samples and assign them to an individual. However, there are circumstances, in which a given DNA sample does not match anyone in the CODIS database, and no other information about the donor is available. In this study, we determined 75 SNPs in 24 genes (previously implicated in human or animal pigmentation studies) for the analysis of single- and multi-locus associations with hair, skin, and eye color in 789 individuals of various ethnic backgrounds. Using multiple linear regression modeling, five SNPs in five genes were found to account for large proportions of pigmentation variation in hair, skin, and eyes in our across-population analyses. Thus, these models may be of predictive value to determine an individual's pigmentation type from a forensic sample, independent of ethnic origin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 315-322 |
| Number of pages | 8 |
| Journal | Journal of Forensic Sciences |
| Volume | 55 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 1 2010 |
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All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
- Genetics
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Predicting phenotype from genotype : Normal pigmentation. / Valenzuela, Robert K.; Henderson, Miquia S.; Walsh, Monica H.; Garrison, Nanibaa A.; Kelch, Jessica T.; Cohen-Barak, Orit; Erickson, Drew T.; John Meaney, F.; Bruce Walsh, J.; Cheng, Keith; Ito, Shosuke; Wakamatsu, Kazumasa; Frudakis, Tony; Thomas, Matthew; Brilliant, Murray H.
In: Journal of Forensic Sciences, Vol. 55, No. 2, 01.03.2010, p. 315-322.Research output: Contribution to journal › Article
TY - JOUR
T1 - Predicting phenotype from genotype
T2 - Normal pigmentation
AU - Valenzuela, Robert K.
AU - Henderson, Miquia S.
AU - Walsh, Monica H.
AU - Garrison, Nanibaa A.
AU - Kelch, Jessica T.
AU - Cohen-Barak, Orit
AU - Erickson, Drew T.
AU - John Meaney, F.
AU - Bruce Walsh, J.
AU - Cheng, Keith
AU - Ito, Shosuke
AU - Wakamatsu, Kazumasa
AU - Frudakis, Tony
AU - Thomas, Matthew
AU - Brilliant, Murray H.
PY - 2010/3/1
Y1 - 2010/3/1
N2 - Genetic information in forensic studies is largely limited to CODIS data and the ability to match samples and assign them to an individual. However, there are circumstances, in which a given DNA sample does not match anyone in the CODIS database, and no other information about the donor is available. In this study, we determined 75 SNPs in 24 genes (previously implicated in human or animal pigmentation studies) for the analysis of single- and multi-locus associations with hair, skin, and eye color in 789 individuals of various ethnic backgrounds. Using multiple linear regression modeling, five SNPs in five genes were found to account for large proportions of pigmentation variation in hair, skin, and eyes in our across-population analyses. Thus, these models may be of predictive value to determine an individual's pigmentation type from a forensic sample, independent of ethnic origin.
AB - Genetic information in forensic studies is largely limited to CODIS data and the ability to match samples and assign them to an individual. However, there are circumstances, in which a given DNA sample does not match anyone in the CODIS database, and no other information about the donor is available. In this study, we determined 75 SNPs in 24 genes (previously implicated in human or animal pigmentation studies) for the analysis of single- and multi-locus associations with hair, skin, and eye color in 789 individuals of various ethnic backgrounds. Using multiple linear regression modeling, five SNPs in five genes were found to account for large proportions of pigmentation variation in hair, skin, and eyes in our across-population analyses. Thus, these models may be of predictive value to determine an individual's pigmentation type from a forensic sample, independent of ethnic origin.
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UR - http://www.scopus.com/inward/citedby.url?scp=77649241464&partnerID=8YFLogxK
U2 - 10.1111/j.1556-4029.2009.01317.x
DO - 10.1111/j.1556-4029.2009.01317.x
M3 - Article
VL - 55
SP - 315
EP - 322
JO - Journal of Forensic Sciences
JF - Journal of Forensic Sciences
SN - 0022-1198
IS - 2
ER -