Predicting phenotype from genotype

Normal pigmentation

Robert K. Valenzuela, Miquia S. Henderson, Monica H. Walsh, Nanibaa A. Garrison, Jessica T. Kelch, Orit Cohen-Barak, Drew T. Erickson, F. John Meaney, J. Bruce Walsh, Keith Cheng, Shosuke Ito, Kazumasa Wakamatsu, Tony Frudakis, Matthew Thomas, Murray H. Brilliant

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Genetic information in forensic studies is largely limited to CODIS data and the ability to match samples and assign them to an individual. However, there are circumstances, in which a given DNA sample does not match anyone in the CODIS database, and no other information about the donor is available. In this study, we determined 75 SNPs in 24 genes (previously implicated in human or animal pigmentation studies) for the analysis of single- and multi-locus associations with hair, skin, and eye color in 789 individuals of various ethnic backgrounds. Using multiple linear regression modeling, five SNPs in five genes were found to account for large proportions of pigmentation variation in hair, skin, and eyes in our across-population analyses. Thus, these models may be of predictive value to determine an individual's pigmentation type from a forensic sample, independent of ethnic origin.

Original languageEnglish (US)
Pages (from-to)315-322
Number of pages8
JournalJournal of Forensic Sciences
Volume55
Issue number2
DOIs
StatePublished - Mar 1 2010

Fingerprint

Pigmentation
Genotype
Phenotype
Single Nucleotide Polymorphism
Hair Color
Eye Color
Skin Pigmentation
Hair
Genes
Linear Models
Databases
Skin
DNA
Population

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Genetics

Cite this

Valenzuela, R. K., Henderson, M. S., Walsh, M. H., Garrison, N. A., Kelch, J. T., Cohen-Barak, O., ... Brilliant, M. H. (2010). Predicting phenotype from genotype: Normal pigmentation. Journal of Forensic Sciences, 55(2), 315-322. https://doi.org/10.1111/j.1556-4029.2009.01317.x
Valenzuela, Robert K. ; Henderson, Miquia S. ; Walsh, Monica H. ; Garrison, Nanibaa A. ; Kelch, Jessica T. ; Cohen-Barak, Orit ; Erickson, Drew T. ; John Meaney, F. ; Bruce Walsh, J. ; Cheng, Keith ; Ito, Shosuke ; Wakamatsu, Kazumasa ; Frudakis, Tony ; Thomas, Matthew ; Brilliant, Murray H. / Predicting phenotype from genotype : Normal pigmentation. In: Journal of Forensic Sciences. 2010 ; Vol. 55, No. 2. pp. 315-322.
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Valenzuela, RK, Henderson, MS, Walsh, MH, Garrison, NA, Kelch, JT, Cohen-Barak, O, Erickson, DT, John Meaney, F, Bruce Walsh, J, Cheng, K, Ito, S, Wakamatsu, K, Frudakis, T, Thomas, M & Brilliant, MH 2010, 'Predicting phenotype from genotype: Normal pigmentation', Journal of Forensic Sciences, vol. 55, no. 2, pp. 315-322. https://doi.org/10.1111/j.1556-4029.2009.01317.x

Predicting phenotype from genotype : Normal pigmentation. / Valenzuela, Robert K.; Henderson, Miquia S.; Walsh, Monica H.; Garrison, Nanibaa A.; Kelch, Jessica T.; Cohen-Barak, Orit; Erickson, Drew T.; John Meaney, F.; Bruce Walsh, J.; Cheng, Keith; Ito, Shosuke; Wakamatsu, Kazumasa; Frudakis, Tony; Thomas, Matthew; Brilliant, Murray H.

In: Journal of Forensic Sciences, Vol. 55, No. 2, 01.03.2010, p. 315-322.

Research output: Contribution to journalArticle

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T2 - Normal pigmentation

AU - Valenzuela, Robert K.

AU - Henderson, Miquia S.

AU - Walsh, Monica H.

AU - Garrison, Nanibaa A.

AU - Kelch, Jessica T.

AU - Cohen-Barak, Orit

AU - Erickson, Drew T.

AU - John Meaney, F.

AU - Bruce Walsh, J.

AU - Cheng, Keith

AU - Ito, Shosuke

AU - Wakamatsu, Kazumasa

AU - Frudakis, Tony

AU - Thomas, Matthew

AU - Brilliant, Murray H.

PY - 2010/3/1

Y1 - 2010/3/1

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AB - Genetic information in forensic studies is largely limited to CODIS data and the ability to match samples and assign them to an individual. However, there are circumstances, in which a given DNA sample does not match anyone in the CODIS database, and no other information about the donor is available. In this study, we determined 75 SNPs in 24 genes (previously implicated in human or animal pigmentation studies) for the analysis of single- and multi-locus associations with hair, skin, and eye color in 789 individuals of various ethnic backgrounds. Using multiple linear regression modeling, five SNPs in five genes were found to account for large proportions of pigmentation variation in hair, skin, and eyes in our across-population analyses. Thus, these models may be of predictive value to determine an individual's pigmentation type from a forensic sample, independent of ethnic origin.

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Valenzuela RK, Henderson MS, Walsh MH, Garrison NA, Kelch JT, Cohen-Barak O et al. Predicting phenotype from genotype: Normal pigmentation. Journal of Forensic Sciences. 2010 Mar 1;55(2):315-322. https://doi.org/10.1111/j.1556-4029.2009.01317.x