TY - JOUR
T1 - Predicting phenotype from genotype
T2 - Normal pigmentation
AU - Valenzuela, Robert K.
AU - Henderson, Miquia S.
AU - Walsh, Monica H.
AU - Garrison, Nanibaa A.
AU - Kelch, Jessica T.
AU - Cohen-Barak, Orit
AU - Erickson, Drew T.
AU - John Meaney, F.
AU - Bruce Walsh, J.
AU - Cheng, Keith C.
AU - Ito, Shosuke
AU - Wakamatsu, Kazumasa
AU - Frudakis, Tony
AU - Thomas, Matthew
AU - Brilliant, Murray H.
PY - 2010/3
Y1 - 2010/3
N2 - Genetic information in forensic studies is largely limited to CODIS data and the ability to match samples and assign them to an individual. However, there are circumstances, in which a given DNA sample does not match anyone in the CODIS database, and no other information about the donor is available. In this study, we determined 75 SNPs in 24 genes (previously implicated in human or animal pigmentation studies) for the analysis of single- and multi-locus associations with hair, skin, and eye color in 789 individuals of various ethnic backgrounds. Using multiple linear regression modeling, five SNPs in five genes were found to account for large proportions of pigmentation variation in hair, skin, and eyes in our across-population analyses. Thus, these models may be of predictive value to determine an individual's pigmentation type from a forensic sample, independent of ethnic origin.
AB - Genetic information in forensic studies is largely limited to CODIS data and the ability to match samples and assign them to an individual. However, there are circumstances, in which a given DNA sample does not match anyone in the CODIS database, and no other information about the donor is available. In this study, we determined 75 SNPs in 24 genes (previously implicated in human or animal pigmentation studies) for the analysis of single- and multi-locus associations with hair, skin, and eye color in 789 individuals of various ethnic backgrounds. Using multiple linear regression modeling, five SNPs in five genes were found to account for large proportions of pigmentation variation in hair, skin, and eyes in our across-population analyses. Thus, these models may be of predictive value to determine an individual's pigmentation type from a forensic sample, independent of ethnic origin.
UR - http://www.scopus.com/inward/record.url?scp=77649241464&partnerID=8YFLogxK
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U2 - 10.1111/j.1556-4029.2009.01317.x
DO - 10.1111/j.1556-4029.2009.01317.x
M3 - Article
C2 - 20158590
AN - SCOPUS:77649241464
VL - 55
SP - 315
EP - 322
JO - Journal of Forensic Sciences
JF - Journal of Forensic Sciences
SN - 0022-1198
IS - 2
ER -