Prediction of heart transplant rejection with a breath test for markers of oxidative stress

Michael Phillips, John P. Boehmer, Renee N. Cataneo, Taseer Cheema, Howard J. Eisen, John T. Fallon, Peter E. Fisher, Alan Gass, Joel Greenberg, Jon Kobashigawa, Donna Mancini, Barry Rayburn, Mark J. Zucker

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

The Heart Allograft Rejection: Detection with Breath Alkanes in Low Levels study evaluated a breath test for oxidative stress in heart transplant recipients, and we report here a mathematical model predicting the probability of grade 3 rejection. The breath test divided the heart transplant recipients into 3 groups: positive for grade 3 rejection, negative for grade 3 rejection, and intermediate. The test was 100% sensitive for grade 3 heart transplant rejection when the p value was ≥0.98, and 100% specific when the p value was ≤0.058; in the intermediate group, the breath test determined the probability of grade 3 rejection and the predictive value of the result.

Original languageEnglish (US)
Pages (from-to)1593-1594
Number of pages2
JournalAmerican Journal of Cardiology
Volume94
Issue number12
DOIs
StatePublished - Dec 15 2004

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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