Prediction of hot spots of ozone flux in a rhesus monkey lung during steady inspiratory flow

Banafsheh Keshavarzi, James S. Ultman, Ali Borhan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A reproducible pattern of tissue injury induced by inhalation of ozone, a ubiquitous air pollutant, is believed to depend on the local dose delivered to the airway walls. To predict the local dose, we performed numerical simulations of ozone transport and uptake in an anatomically-accurate model of the respiratory tract of a Rhesus monkey. The model geometry was created using three-dimensional reconstruction of the MRI data for the nose, the larynx, and the lung. An unstructured mesh was generated for the resulting structure, and three-dimensional flow and concentration distributions were obtained through numerical solution of the Navier-Stokes, continuity, and species convection-diffusion equations. A quasi-steady diffusion-reaction model was used to account for the interaction between ozone and endogenous substrates in the respiratory tract lining fluid (RTLF). The total rate of ozone uptake within each section of the respiratory tract was determined, and hot spots of ozone flux on the airway walls were identified.

Original languageEnglish (US)
Title of host publication2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012
Pages53-54
Number of pages2
DOIs
StatePublished - 2012
Event38th Annual Northeast Bioengineering Conference, NEBEC 2012 - Philadelphia, PA, United States
Duration: Mar 16 2012Mar 18 2012

Other

Other38th Annual Northeast Bioengineering Conference, NEBEC 2012
CountryUnited States
CityPhiladelphia, PA
Period3/16/123/18/12

Fingerprint

Ozone
Steady flow
Fluxes
Air Pollutants
Linings
Magnetic resonance imaging
Tissue
Fluids
Geometry
Computer simulation
Substrates
Air

All Science Journal Classification (ASJC) codes

  • Bioengineering

Cite this

Keshavarzi, B., Ultman, J. S., & Borhan, A. (2012). Prediction of hot spots of ozone flux in a rhesus monkey lung during steady inspiratory flow. In 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012 (pp. 53-54). [6206958] https://doi.org/10.1109/NEBC.2012.6206958
Keshavarzi, Banafsheh ; Ultman, James S. ; Borhan, Ali. / Prediction of hot spots of ozone flux in a rhesus monkey lung during steady inspiratory flow. 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012. 2012. pp. 53-54
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Keshavarzi, B, Ultman, JS & Borhan, A 2012, Prediction of hot spots of ozone flux in a rhesus monkey lung during steady inspiratory flow. in 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012., 6206958, pp. 53-54, 38th Annual Northeast Bioengineering Conference, NEBEC 2012, Philadelphia, PA, United States, 3/16/12. https://doi.org/10.1109/NEBC.2012.6206958

Prediction of hot spots of ozone flux in a rhesus monkey lung during steady inspiratory flow. / Keshavarzi, Banafsheh; Ultman, James S.; Borhan, Ali.

2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012. 2012. p. 53-54 6206958.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AB - A reproducible pattern of tissue injury induced by inhalation of ozone, a ubiquitous air pollutant, is believed to depend on the local dose delivered to the airway walls. To predict the local dose, we performed numerical simulations of ozone transport and uptake in an anatomically-accurate model of the respiratory tract of a Rhesus monkey. The model geometry was created using three-dimensional reconstruction of the MRI data for the nose, the larynx, and the lung. An unstructured mesh was generated for the resulting structure, and three-dimensional flow and concentration distributions were obtained through numerical solution of the Navier-Stokes, continuity, and species convection-diffusion equations. A quasi-steady diffusion-reaction model was used to account for the interaction between ozone and endogenous substrates in the respiratory tract lining fluid (RTLF). The total rate of ozone uptake within each section of the respiratory tract was determined, and hot spots of ozone flux on the airway walls were identified.

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Keshavarzi B, Ultman JS, Borhan A. Prediction of hot spots of ozone flux in a rhesus monkey lung during steady inspiratory flow. In 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012. 2012. p. 53-54. 6206958 https://doi.org/10.1109/NEBC.2012.6206958