Predictive factors of recurrence and survival of upper tract urothelial carcinomas

Grégory Verhoest, Shahrokh F. Shariat, Thomas F. Chromecki, Jay Raman, Vitaly Margulis, Giacomo Novara, Christian Seitz, Mesut Remzi, Morgan Rouprêt, Douglas S. Scherr, Karim Bensalah

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Objective: UTUCC is a rare tumor, and most reports on prognostic factors come from small single-center series. The objective of this article was to provide an updated overview of current clinical, pathological and biological prognostic factors of UTUC. Methods: PubMed was searched for records from 2002 to 2010 using the terms "prognostic factors", "recurrence", "survival", and "upper tract urothelial carcinoma". Among identified citations, papers were selected based on their clinical relevance. Results: Classical clinical factors that influence UTUC prognosis include age, presence of symptoms, hydronephrosis, and interval from diagnosis. Many biomarkers have shown promises to better appraise the natural course of UTUC although none is currently used in clinical practice. Stage, grade, lymph node metastases, lymphovascular invasion, tumor necrosis, and tumor architecture are strong pathological parameters. RNU is the standard treatment of localized UTUC. Both laparoscopic and open approaches seem to offer similar cancer control. Lymph node dissection increases staging accuracy and might confer a survival benefit. Conclusion: RNU is the standard treatment for most patients with UTUC. Recent multicenter studies confirmed the prognostic value of classical prognostic parameters. Better survival prediction might be obtained with prognostic systems including clinical data and new biomarkers.

Original languageEnglish (US)
Pages (from-to)495-501
Number of pages7
JournalWorld Journal of Urology
Volume29
Issue number4
DOIs
StatePublished - Aug 1 2011

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Carcinoma
Recurrence
Survival
Neoplasms
Biomarkers
Hydronephrosis
Biological Factors
Lymph Node Excision
PubMed
Multicenter Studies
Necrosis
Lymph Nodes
Neoplasm Metastasis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Verhoest, G., Shariat, S. F., Chromecki, T. F., Raman, J., Margulis, V., Novara, G., ... Bensalah, K. (2011). Predictive factors of recurrence and survival of upper tract urothelial carcinomas. World Journal of Urology, 29(4), 495-501. https://doi.org/10.1007/s00345-011-0710-3
Verhoest, Grégory ; Shariat, Shahrokh F. ; Chromecki, Thomas F. ; Raman, Jay ; Margulis, Vitaly ; Novara, Giacomo ; Seitz, Christian ; Remzi, Mesut ; Rouprêt, Morgan ; Scherr, Douglas S. ; Bensalah, Karim. / Predictive factors of recurrence and survival of upper tract urothelial carcinomas. In: World Journal of Urology. 2011 ; Vol. 29, No. 4. pp. 495-501.
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Verhoest, G, Shariat, SF, Chromecki, TF, Raman, J, Margulis, V, Novara, G, Seitz, C, Remzi, M, Rouprêt, M, Scherr, DS & Bensalah, K 2011, 'Predictive factors of recurrence and survival of upper tract urothelial carcinomas', World Journal of Urology, vol. 29, no. 4, pp. 495-501. https://doi.org/10.1007/s00345-011-0710-3

Predictive factors of recurrence and survival of upper tract urothelial carcinomas. / Verhoest, Grégory; Shariat, Shahrokh F.; Chromecki, Thomas F.; Raman, Jay; Margulis, Vitaly; Novara, Giacomo; Seitz, Christian; Remzi, Mesut; Rouprêt, Morgan; Scherr, Douglas S.; Bensalah, Karim.

In: World Journal of Urology, Vol. 29, No. 4, 01.08.2011, p. 495-501.

Research output: Contribution to journalArticle

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AU - Verhoest, Grégory

AU - Shariat, Shahrokh F.

AU - Chromecki, Thomas F.

AU - Raman, Jay

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AU - Novara, Giacomo

AU - Seitz, Christian

AU - Remzi, Mesut

AU - Rouprêt, Morgan

AU - Scherr, Douglas S.

AU - Bensalah, Karim

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N2 - Objective: UTUCC is a rare tumor, and most reports on prognostic factors come from small single-center series. The objective of this article was to provide an updated overview of current clinical, pathological and biological prognostic factors of UTUC. Methods: PubMed was searched for records from 2002 to 2010 using the terms "prognostic factors", "recurrence", "survival", and "upper tract urothelial carcinoma". Among identified citations, papers were selected based on their clinical relevance. Results: Classical clinical factors that influence UTUC prognosis include age, presence of symptoms, hydronephrosis, and interval from diagnosis. Many biomarkers have shown promises to better appraise the natural course of UTUC although none is currently used in clinical practice. Stage, grade, lymph node metastases, lymphovascular invasion, tumor necrosis, and tumor architecture are strong pathological parameters. RNU is the standard treatment of localized UTUC. Both laparoscopic and open approaches seem to offer similar cancer control. Lymph node dissection increases staging accuracy and might confer a survival benefit. Conclusion: RNU is the standard treatment for most patients with UTUC. Recent multicenter studies confirmed the prognostic value of classical prognostic parameters. Better survival prediction might be obtained with prognostic systems including clinical data and new biomarkers.

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