Predictors of large and small artery elasticity in healthy subjects from 9 to 89 years old

Andrew W. Gardner, Donald E. Parker

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

BackgroundWe identified demographic variables, cardiovascular risk factors, and ambulatory activity measures that predict large and small artery elasticity in apparently healthy subjects between 9 and 89 years of age.MethodsA total of 480 subjects were assessed on large artery elasticity index (LAEI), small artery elasticity index (SAEI), demographic measures, cardiovascular risk factors, and daily ambulation during 7 consecutive days. All possible regression and Mallow's Cp were used to select multivariate models for prediction of LAEI and SAEI.ResultsIn subjects 20 years of age and younger, LAEI model (R2 = 0.25, P <0.001) included age, average ambulatory cadence, and obesity. SAEI model (R2 = 0.39, P <0.001) contained body mass index (BMI), maximum daily ambulatory cadence for 30 continuous min, age, and total ambulatory strides. In subjects between 21 and 50 years, LAEI model (R2 = 0.41, P <0.001) included systolic blood pressure (SBP), gender, race, and diastolic blood pressure (DBP). SAEI model (R2 = 0.42, P <0.001) contained gender, BMI, DBP, race, dyslipidemia, and SBP. In subjects older than 50 years, LAEI model (R2 = 0.54, P <0.001) included SBP, gender, age, and BMI. SAEI model (R2 = 0.45, P <0.001) contained gender, age, BMI, DBP, current smoking, and SBP.ConclusionsDaily ambulatory activity, particularly cadence of 30 continuous min of ambulation, is positively associated with arterial elasticity in children and adolescents. In contrast, the predominant factors related to the decline in arterial elasticity in adults are blood pressure and age.

Original languageEnglish (US)
Pages (from-to)599-605
Number of pages7
JournalAmerican journal of hypertension
Volume24
Issue number5
DOIs
StatePublished - May 2011

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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