Predictors of serum dioxin, furan, and PCB concentrations among women from chapaevsk, Russia

Olivier Humblet, Paige L. Williams, Susan A. Korrick, Oleg Sergeyev, Claude Emond, Linda S. Birnbaum, Jane S. Burns, Larisa Altshul, Donald G. Patterson, Wayman E. Turner, Mary M. Lee, Boris Revich, Russ Hauser

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Dioxins, furans, and polychlorinated biphenyls (PCBs) are persistent and bioaccumulative toxic chemicals that are ubiquitous in the environment. We assessed predictors of their serum concentrations among women living in a Russian town contaminated by past industrial activity. Blood samples from 446 mothers aged 23-52 years were collected between 2003-2005 as part of the Russian Children's Study. Serum dioxin, furan, and PCB concentrations were quantified using high-resolution gas chromatography-mass spectrometry. Potential determinants of exposure were collected through interviews. Multivariate linear regression models were used to identify predictors of serum concentrations and toxic equivalencies (TEQs). The median total PCB concentrations and total TEQs were 260 ng/g lipid and 25 pg TEQ/g lipid, respectively. In multivariate analyses, both total PCB concentrations and total TEQs increased significantly with age, residential proximity to a local chemical plant, duration of local farming, and consumption of local beef. Both decreased with longer breastfeeding, recent increases in body mass index, and later blood draw date. These demographic and lifestyle predictors showed generally similar associations with the various measures of serum dioxins, furans, and PCBs.

Original languageEnglish (US)
Pages (from-to)5633-5640
Number of pages8
JournalEnvironmental Science and Technology
Volume44
Issue number14
DOIs
StatePublished - Jul 15 2010

Fingerprint

Dioxins
furan
Poisons
Polychlorinated Biphenyls
dioxin
serum
PCB
Furans
Blood
blood
lipid
breastfeeding
Lipids
Beef
Chemical plants
lifestyle
Linear regression
Gas chromatography
body mass
Mass spectrometry

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Environmental Chemistry

Cite this

Humblet, O., Williams, P. L., Korrick, S. A., Sergeyev, O., Emond, C., Birnbaum, L. S., ... Hauser, R. (2010). Predictors of serum dioxin, furan, and PCB concentrations among women from chapaevsk, Russia. Environmental Science and Technology, 44(14), 5633-5640. https://doi.org/10.1021/es100976j
Humblet, Olivier ; Williams, Paige L. ; Korrick, Susan A. ; Sergeyev, Oleg ; Emond, Claude ; Birnbaum, Linda S. ; Burns, Jane S. ; Altshul, Larisa ; Patterson, Donald G. ; Turner, Wayman E. ; Lee, Mary M. ; Revich, Boris ; Hauser, Russ. / Predictors of serum dioxin, furan, and PCB concentrations among women from chapaevsk, Russia. In: Environmental Science and Technology. 2010 ; Vol. 44, No. 14. pp. 5633-5640.
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Humblet, O, Williams, PL, Korrick, SA, Sergeyev, O, Emond, C, Birnbaum, LS, Burns, JS, Altshul, L, Patterson, DG, Turner, WE, Lee, MM, Revich, B & Hauser, R 2010, 'Predictors of serum dioxin, furan, and PCB concentrations among women from chapaevsk, Russia', Environmental Science and Technology, vol. 44, no. 14, pp. 5633-5640. https://doi.org/10.1021/es100976j

Predictors of serum dioxin, furan, and PCB concentrations among women from chapaevsk, Russia. / Humblet, Olivier; Williams, Paige L.; Korrick, Susan A.; Sergeyev, Oleg; Emond, Claude; Birnbaum, Linda S.; Burns, Jane S.; Altshul, Larisa; Patterson, Donald G.; Turner, Wayman E.; Lee, Mary M.; Revich, Boris; Hauser, Russ.

In: Environmental Science and Technology, Vol. 44, No. 14, 15.07.2010, p. 5633-5640.

Research output: Contribution to journalArticle

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T1 - Predictors of serum dioxin, furan, and PCB concentrations among women from chapaevsk, Russia

AU - Humblet, Olivier

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AU - Emond, Claude

AU - Birnbaum, Linda S.

AU - Burns, Jane S.

AU - Altshul, Larisa

AU - Patterson, Donald G.

AU - Turner, Wayman E.

AU - Lee, Mary M.

AU - Revich, Boris

AU - Hauser, Russ

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N2 - Dioxins, furans, and polychlorinated biphenyls (PCBs) are persistent and bioaccumulative toxic chemicals that are ubiquitous in the environment. We assessed predictors of their serum concentrations among women living in a Russian town contaminated by past industrial activity. Blood samples from 446 mothers aged 23-52 years were collected between 2003-2005 as part of the Russian Children's Study. Serum dioxin, furan, and PCB concentrations were quantified using high-resolution gas chromatography-mass spectrometry. Potential determinants of exposure were collected through interviews. Multivariate linear regression models were used to identify predictors of serum concentrations and toxic equivalencies (TEQs). The median total PCB concentrations and total TEQs were 260 ng/g lipid and 25 pg TEQ/g lipid, respectively. In multivariate analyses, both total PCB concentrations and total TEQs increased significantly with age, residential proximity to a local chemical plant, duration of local farming, and consumption of local beef. Both decreased with longer breastfeeding, recent increases in body mass index, and later blood draw date. These demographic and lifestyle predictors showed generally similar associations with the various measures of serum dioxins, furans, and PCBs.

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Humblet O, Williams PL, Korrick SA, Sergeyev O, Emond C, Birnbaum LS et al. Predictors of serum dioxin, furan, and PCB concentrations among women from chapaevsk, Russia. Environmental Science and Technology. 2010 Jul 15;44(14):5633-5640. https://doi.org/10.1021/es100976j