Predictors of serum dioxins and PCBs among peripubertal Russian boys

Jane S. Burns, Paige L. Williams, Oleg Sergeyev, Susan Korrick, Mary M. Lee, Boris Revich, Larisa Altshul, Donald George Jr Patterson, Wayman E. Turner, Larry L. Needham, Igor Saharov, Russ Hauser

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

BACKGROUND: Although sources and routes of exposure to dioxins and polychlorinated biphenyls (PCBs) have been studied, information regarding exposure among children is limited. Breast-feeding and diet are two important contributors to early life exposure. To further understand other significant contributors to childhood exposure, we studied a cohort of children from a city with high environmental dioxin levels. OBJECTIVES: We investigated predictors of serum concentrations of polychlorinated dibenzo-p-dioxins (PCDDs)/ polychlorinated dibenzofurans (PCDFs)/co-planar PCBs (C-PCBs), toxic equivalents (TEQs), and PCBs among 8- to 9-year-old boys in Chapaevsk, Russia. METHODS: We used general linear regression models to explore associations of log10-transformed serum concentrations of PCDDs/PCDFs/C-PCBs, TEQs, and PCBs at study entry with anthropometric, demographic, geographic, and dietary factors in 482 boys in Chapaevsk, Russia. RESULTS: The median (25th, 75th percentile) concentration for total 2005 TEQs was 21.1 pg/g lipid (14.4, 33.2). Boys who were older, consumed local foods, were breast-fed longer, and whose mothers were employed at the Khimprom chemical plant (where chlorinated chemicals were produced) or gardened locally had significantly higher serum dioxins and PCBs, whereas boys with higher body mass index or more educated parents had significantly lower serum dioxins and PCBs. Boys who lived < 2 km from Khimprom had higher total TEQs (picograms per gram lipid) [adjusted mean = 30.6; 95% confidence interval (CI), 26.8-35.0] than boys who lived > 5 km away (adjusted mean = 18.8; 95% CI, 17.2-20.6). CONCLUSIONS: Our findings suggest that there are specific local sources of dioxin and PCB exposure among children in Chapaevsk including maternal gardening, consumption of locally grown food, and residential proximity to the Khimprom plant.

Original languageEnglish (US)
Pages (from-to)1593-1599
Number of pages7
JournalEnvironmental health perspectives
Volume117
Issue number10
DOIs
StatePublished - Oct 1 2009

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Dioxins
Polychlorinated Biphenyls
Serum
Poisons
Russia
Linear Models
Gardening
Mothers
Food
Geography
Breast Feeding
Breast
Body Mass Index
Parents
Demography
Diet
Lipids

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Burns, J. S., Williams, P. L., Sergeyev, O., Korrick, S., Lee, M. M., Revich, B., ... Hauser, R. (2009). Predictors of serum dioxins and PCBs among peripubertal Russian boys. Environmental health perspectives, 117(10), 1593-1599. https://doi.org/10.1289/ehp.0800223
Burns, Jane S. ; Williams, Paige L. ; Sergeyev, Oleg ; Korrick, Susan ; Lee, Mary M. ; Revich, Boris ; Altshul, Larisa ; Patterson, Donald George Jr ; Turner, Wayman E. ; Needham, Larry L. ; Saharov, Igor ; Hauser, Russ. / Predictors of serum dioxins and PCBs among peripubertal Russian boys. In: Environmental health perspectives. 2009 ; Vol. 117, No. 10. pp. 1593-1599.
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Burns, JS, Williams, PL, Sergeyev, O, Korrick, S, Lee, MM, Revich, B, Altshul, L, Patterson, DGJ, Turner, WE, Needham, LL, Saharov, I & Hauser, R 2009, 'Predictors of serum dioxins and PCBs among peripubertal Russian boys', Environmental health perspectives, vol. 117, no. 10, pp. 1593-1599. https://doi.org/10.1289/ehp.0800223

Predictors of serum dioxins and PCBs among peripubertal Russian boys. / Burns, Jane S.; Williams, Paige L.; Sergeyev, Oleg; Korrick, Susan; Lee, Mary M.; Revich, Boris; Altshul, Larisa; Patterson, Donald George Jr; Turner, Wayman E.; Needham, Larry L.; Saharov, Igor; Hauser, Russ.

In: Environmental health perspectives, Vol. 117, No. 10, 01.10.2009, p. 1593-1599.

Research output: Contribution to journalArticle

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T1 - Predictors of serum dioxins and PCBs among peripubertal Russian boys

AU - Burns, Jane S.

AU - Williams, Paige L.

AU - Sergeyev, Oleg

AU - Korrick, Susan

AU - Lee, Mary M.

AU - Revich, Boris

AU - Altshul, Larisa

AU - Patterson, Donald George Jr

AU - Turner, Wayman E.

AU - Needham, Larry L.

AU - Saharov, Igor

AU - Hauser, Russ

PY - 2009/10/1

Y1 - 2009/10/1

N2 - BACKGROUND: Although sources and routes of exposure to dioxins and polychlorinated biphenyls (PCBs) have been studied, information regarding exposure among children is limited. Breast-feeding and diet are two important contributors to early life exposure. To further understand other significant contributors to childhood exposure, we studied a cohort of children from a city with high environmental dioxin levels. OBJECTIVES: We investigated predictors of serum concentrations of polychlorinated dibenzo-p-dioxins (PCDDs)/ polychlorinated dibenzofurans (PCDFs)/co-planar PCBs (C-PCBs), toxic equivalents (TEQs), and PCBs among 8- to 9-year-old boys in Chapaevsk, Russia. METHODS: We used general linear regression models to explore associations of log10-transformed serum concentrations of PCDDs/PCDFs/C-PCBs, TEQs, and PCBs at study entry with anthropometric, demographic, geographic, and dietary factors in 482 boys in Chapaevsk, Russia. RESULTS: The median (25th, 75th percentile) concentration for total 2005 TEQs was 21.1 pg/g lipid (14.4, 33.2). Boys who were older, consumed local foods, were breast-fed longer, and whose mothers were employed at the Khimprom chemical plant (where chlorinated chemicals were produced) or gardened locally had significantly higher serum dioxins and PCBs, whereas boys with higher body mass index or more educated parents had significantly lower serum dioxins and PCBs. Boys who lived < 2 km from Khimprom had higher total TEQs (picograms per gram lipid) [adjusted mean = 30.6; 95% confidence interval (CI), 26.8-35.0] than boys who lived > 5 km away (adjusted mean = 18.8; 95% CI, 17.2-20.6). CONCLUSIONS: Our findings suggest that there are specific local sources of dioxin and PCB exposure among children in Chapaevsk including maternal gardening, consumption of locally grown food, and residential proximity to the Khimprom plant.

AB - BACKGROUND: Although sources and routes of exposure to dioxins and polychlorinated biphenyls (PCBs) have been studied, information regarding exposure among children is limited. Breast-feeding and diet are two important contributors to early life exposure. To further understand other significant contributors to childhood exposure, we studied a cohort of children from a city with high environmental dioxin levels. OBJECTIVES: We investigated predictors of serum concentrations of polychlorinated dibenzo-p-dioxins (PCDDs)/ polychlorinated dibenzofurans (PCDFs)/co-planar PCBs (C-PCBs), toxic equivalents (TEQs), and PCBs among 8- to 9-year-old boys in Chapaevsk, Russia. METHODS: We used general linear regression models to explore associations of log10-transformed serum concentrations of PCDDs/PCDFs/C-PCBs, TEQs, and PCBs at study entry with anthropometric, demographic, geographic, and dietary factors in 482 boys in Chapaevsk, Russia. RESULTS: The median (25th, 75th percentile) concentration for total 2005 TEQs was 21.1 pg/g lipid (14.4, 33.2). Boys who were older, consumed local foods, were breast-fed longer, and whose mothers were employed at the Khimprom chemical plant (where chlorinated chemicals were produced) or gardened locally had significantly higher serum dioxins and PCBs, whereas boys with higher body mass index or more educated parents had significantly lower serum dioxins and PCBs. Boys who lived < 2 km from Khimprom had higher total TEQs (picograms per gram lipid) [adjusted mean = 30.6; 95% confidence interval (CI), 26.8-35.0] than boys who lived > 5 km away (adjusted mean = 18.8; 95% CI, 17.2-20.6). CONCLUSIONS: Our findings suggest that there are specific local sources of dioxin and PCB exposure among children in Chapaevsk including maternal gardening, consumption of locally grown food, and residential proximity to the Khimprom plant.

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Burns JS, Williams PL, Sergeyev O, Korrick S, Lee MM, Revich B et al. Predictors of serum dioxins and PCBs among peripubertal Russian boys. Environmental health perspectives. 2009 Oct 1;117(10):1593-1599. https://doi.org/10.1289/ehp.0800223