Pregabalin enhances nonrapid eye movement sleep

Takeshi Kubota, Jidong Fang, Leonard T. Meltzer, James M. Krueger

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Pregabalin, an analog of γ,-aminobutyric acid (GABA) that does not interact with GABA receptors, is in development as an analgesic, an anticonvulsant, and an anxiolytic. We evaluated the potential somnogenic actions of pregabalin in rats and compared it to those of triazolam, a widely used hypnotic. Pregabalin increased the duration of nonrapid eye movement sleep (NREMS) and decreased rapid eye movement sleep (REMS) after either dark onset or light onset administration. Triazolam increased duration of NREMS and had no effect on duration of REMS. Pregabalin markedly increased the duration of NREMS episodes and decreased the number of NREMS episodes. Power spectrum analysis revealed pregabalin-induced dose-dependent increases in relative delta power after administration. In contrast, triazolam decreased electroencephalographic power density in low frequency bands. Results suggest that pregabalin is a potential sleep modulating agent.

Original languageEnglish (US)
Pages (from-to)1095-1105
Number of pages11
JournalJournal of Pharmacology and Experimental Therapeutics
Volume299
Issue number3
StatePublished - Dec 12 2001

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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