Preliminary studies on the effect of moderate physical activity on blood levels of glutathione

A. G. Rundle, M. Orjuela, L. Mooney, D. Tang, M. Kim, A. Galcagnotto, J. P. Richie, F. Perera

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Molecular epidemiological approaches are being used to study how physical activity may protect against cancer. Prior epidemiological data suggest that physical activity protects against lung cancer; however, interpretation of these data is complicated by potential confounding by smoking. Glutathione (GSH) detoxifies cigarette smoke carcinogens and the paper tests whether physical activity levels are associated with blood GSH levels. Study subjects were enrolled in a chemoprevention trial testing whether antioxidant micronutrient supplementation reduces genetic damage from cigarette smoking. Physical activity data were collected by questionnaire from 178 subjects at 12 months of follow-up in the trial. Total GSH (tGSH), which is the sum of free and protein-bound GSH and glutathione disulfide levels, was measured using the 5,5′-dithiobis-(2-nitrobenzenoic acid) colormetric assay with red blood cell samples collected at the 12-month time point. In multivariate linear regression analyses that controlled for gender and cigarettes smoked per day, tGSH was positively associated with hours per week of moderate intensity activity (β = 0.005, p = 0.02). Hours per week of vigorous intensity activity were unassociated with tGSH and the effect of moderate activity remained after control for vigorous activity. The results are consistent with prior research showing differential effects of moderate and vigorous activity and suggest a mechanism through which physical activity may influence lung cancer risk.

Original languageEnglish (US)
Pages (from-to)390-400
Number of pages11
JournalBiomarkers
Volume10
Issue number5
DOIs
StatePublished - Sep 1 2005

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Tobacco Products
Glutathione
Lung Neoplasms
Blood
Smoking
Carcinogenicity Tests
Glutathione Disulfide
Micronutrients
Chemoprevention
Smoke
Linear Models
Antioxidants
Erythrocytes
Regression Analysis
Linear regression
Carcinogens
Acids
Assays
Cells
Research

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

Cite this

Rundle, A. G., Orjuela, M., Mooney, L., Tang, D., Kim, M., Galcagnotto, A., ... Perera, F. (2005). Preliminary studies on the effect of moderate physical activity on blood levels of glutathione. Biomarkers, 10(5), 390-400. https://doi.org/10.1080/13547500500272663
Rundle, A. G. ; Orjuela, M. ; Mooney, L. ; Tang, D. ; Kim, M. ; Galcagnotto, A. ; Richie, J. P. ; Perera, F. / Preliminary studies on the effect of moderate physical activity on blood levels of glutathione. In: Biomarkers. 2005 ; Vol. 10, No. 5. pp. 390-400.
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Rundle, AG, Orjuela, M, Mooney, L, Tang, D, Kim, M, Galcagnotto, A, Richie, JP & Perera, F 2005, 'Preliminary studies on the effect of moderate physical activity on blood levels of glutathione', Biomarkers, vol. 10, no. 5, pp. 390-400. https://doi.org/10.1080/13547500500272663

Preliminary studies on the effect of moderate physical activity on blood levels of glutathione. / Rundle, A. G.; Orjuela, M.; Mooney, L.; Tang, D.; Kim, M.; Galcagnotto, A.; Richie, J. P.; Perera, F.

In: Biomarkers, Vol. 10, No. 5, 01.09.2005, p. 390-400.

Research output: Contribution to journalArticle

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Rundle AG, Orjuela M, Mooney L, Tang D, Kim M, Galcagnotto A et al. Preliminary studies on the effect of moderate physical activity on blood levels of glutathione. Biomarkers. 2005 Sep 1;10(5):390-400. https://doi.org/10.1080/13547500500272663