Preliminary study of light-cured hydrogel for endodontic drug delivery vehicle

Takashi Komabayashi, Aniket Wadajkar, Sonia Santimano, Chul Ahn, Qiang Zhu, Lynn A. Opperman, Larry L. Bellinger, Jian Yang, Kytai T. Nguyen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

AIM: Direct pulp capping is the treatment of an exposed vital pulp with a dental material to facilitate the formation of reparative dentin and maintenance of vital pulp. A bioengineered drug delivery vehicle has the potential to increase the success rate of pulp capping. The aim of this study was to develop an injectable and light-curing drug delivery vehicle for endodontic treatment including direct pulp capping.

METHODS: Polyethylene glycol-maleate-citrate (PEGMC) hydrogel was synthesized as a drug delivery vehicle that is composed of PEGMC (45% w/v), acrylic acid (AA) (5% w/v), 2,2'-azobis(2-methylpropionamidine) dihydrochloride (AAPH) (0.1% w/v), and deionized water. The association between prehydrogel-solution volume and visible light-curing was examined. The cytotoxicity of the hydrogel was tested using L929 cells in a cell culture system. Ca(2+) release from the hydrogel was determined using calcium hydroxide as the incorporated medicine.

RESULTS: The results showed that the light-curing time for hydrogel is comparable to composite resin. The hydrogel had cell toxicity similar to adhesive systems. Moreover, controlled Ca(2+) release was obtained from the calcium hydroxide incorporated hydrogel.

CONCLUSIONS: The data suggest that hydrogel should be explored further as a promising drug delivery vehicle for vital pulp therapy and regenerative endodontics.

Original languageEnglish (US)
Pages (from-to)87-92
Number of pages6
JournalJournal of investigative and clinical dentistry
Volume7
Issue number1
DOIs
StatePublished - Feb 1 2016

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Hydrogel
Endodontics
Dental Pulp Capping
Light
Pharmaceutical Preparations
Calcium Hydroxide
Dental Materials
Composite Resins
Dentin
Adhesives
Therapeutics
Cell Culture Techniques
Maintenance
Medicine
Injections
Water

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

Komabayashi, T., Wadajkar, A., Santimano, S., Ahn, C., Zhu, Q., Opperman, L. A., ... Nguyen, K. T. (2016). Preliminary study of light-cured hydrogel for endodontic drug delivery vehicle. Journal of investigative and clinical dentistry, 7(1), 87-92. https://doi.org/10.1111/jicd.12118
Komabayashi, Takashi ; Wadajkar, Aniket ; Santimano, Sonia ; Ahn, Chul ; Zhu, Qiang ; Opperman, Lynn A. ; Bellinger, Larry L. ; Yang, Jian ; Nguyen, Kytai T. / Preliminary study of light-cured hydrogel for endodontic drug delivery vehicle. In: Journal of investigative and clinical dentistry. 2016 ; Vol. 7, No. 1. pp. 87-92.
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Komabayashi, T, Wadajkar, A, Santimano, S, Ahn, C, Zhu, Q, Opperman, LA, Bellinger, LL, Yang, J & Nguyen, KT 2016, 'Preliminary study of light-cured hydrogel for endodontic drug delivery vehicle', Journal of investigative and clinical dentistry, vol. 7, no. 1, pp. 87-92. https://doi.org/10.1111/jicd.12118

Preliminary study of light-cured hydrogel for endodontic drug delivery vehicle. / Komabayashi, Takashi; Wadajkar, Aniket; Santimano, Sonia; Ahn, Chul; Zhu, Qiang; Opperman, Lynn A.; Bellinger, Larry L.; Yang, Jian; Nguyen, Kytai T.

In: Journal of investigative and clinical dentistry, Vol. 7, No. 1, 01.02.2016, p. 87-92.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Preliminary study of light-cured hydrogel for endodontic drug delivery vehicle

AU - Komabayashi, Takashi

AU - Wadajkar, Aniket

AU - Santimano, Sonia

AU - Ahn, Chul

AU - Zhu, Qiang

AU - Opperman, Lynn A.

AU - Bellinger, Larry L.

AU - Yang, Jian

AU - Nguyen, Kytai T.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - AIM: Direct pulp capping is the treatment of an exposed vital pulp with a dental material to facilitate the formation of reparative dentin and maintenance of vital pulp. A bioengineered drug delivery vehicle has the potential to increase the success rate of pulp capping. The aim of this study was to develop an injectable and light-curing drug delivery vehicle for endodontic treatment including direct pulp capping.METHODS: Polyethylene glycol-maleate-citrate (PEGMC) hydrogel was synthesized as a drug delivery vehicle that is composed of PEGMC (45% w/v), acrylic acid (AA) (5% w/v), 2,2'-azobis(2-methylpropionamidine) dihydrochloride (AAPH) (0.1% w/v), and deionized water. The association between prehydrogel-solution volume and visible light-curing was examined. The cytotoxicity of the hydrogel was tested using L929 cells in a cell culture system. Ca(2+) release from the hydrogel was determined using calcium hydroxide as the incorporated medicine.RESULTS: The results showed that the light-curing time for hydrogel is comparable to composite resin. The hydrogel had cell toxicity similar to adhesive systems. Moreover, controlled Ca(2+) release was obtained from the calcium hydroxide incorporated hydrogel.CONCLUSIONS: The data suggest that hydrogel should be explored further as a promising drug delivery vehicle for vital pulp therapy and regenerative endodontics.

AB - AIM: Direct pulp capping is the treatment of an exposed vital pulp with a dental material to facilitate the formation of reparative dentin and maintenance of vital pulp. A bioengineered drug delivery vehicle has the potential to increase the success rate of pulp capping. The aim of this study was to develop an injectable and light-curing drug delivery vehicle for endodontic treatment including direct pulp capping.METHODS: Polyethylene glycol-maleate-citrate (PEGMC) hydrogel was synthesized as a drug delivery vehicle that is composed of PEGMC (45% w/v), acrylic acid (AA) (5% w/v), 2,2'-azobis(2-methylpropionamidine) dihydrochloride (AAPH) (0.1% w/v), and deionized water. The association between prehydrogel-solution volume and visible light-curing was examined. The cytotoxicity of the hydrogel was tested using L929 cells in a cell culture system. Ca(2+) release from the hydrogel was determined using calcium hydroxide as the incorporated medicine.RESULTS: The results showed that the light-curing time for hydrogel is comparable to composite resin. The hydrogel had cell toxicity similar to adhesive systems. Moreover, controlled Ca(2+) release was obtained from the calcium hydroxide incorporated hydrogel.CONCLUSIONS: The data suggest that hydrogel should be explored further as a promising drug delivery vehicle for vital pulp therapy and regenerative endodontics.

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U2 - 10.1111/jicd.12118

DO - 10.1111/jicd.12118

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