Prenatal and perinatal complications

Is it the link between race and SES and childhood sleep disordered breathing?

Susan Calhoun, Alexandros Vgontzas, Susan Mayes, Marina Tsaoussoglou, Katherine Sauder, Fauzia Mahr, Anoop Karippot, Krista Wisner, Edward Bixler

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Study Objectives: Recent evidence has suggested that low socioeconomic status (SES), race, prematurity, and maternal smoking during pregnancy are associated with childhood sleep disordered breathing (SDB). We investigated (1) the association of SDB with a wide range of risk factors, including prenatal and perinatal complications; (2) the association of these complications with SES and race; and (3) the association of SDB with developmental milestones. Methods: Six hundred thirteen school-aged children (105 clinically referred and 508 community control subjects) underwent overnight polysomnography and had a complete history and physical examination. A comprehensive child development questionnaire was completed by a parent. We compared clinically referred children with SDB to population-based control children without SDB from The Penn State Children's Cohort. Results: Maternal smoking during pregnancy; maternal age and weight gain during pregnancy; prenatal complications, such as maternal high blood pressure and gestational diabetes; perinatal complications related to prematurity; delayed motor milestones; race and SES were significantly associated with the presence of childhood SDB. Most of the risk factors became nonsignificant when analyses controlled for race and SES. Delayed motor milestones remained significantly associated with SDB after controlling for race and SES. Conclusion: These data suggest that there is a significant association between children who experience prenatal or perinatal distress and the development of moderate to severe childhood SDB. SES and race may be mediating the impact on SDB through increased prenatal and perinatal risks. The significant delay in motor milestones suggests that prenatal and perinatal distress may result in neurologic insult, which could influence the development of SDB in later childhood.

Original languageEnglish (US)
Pages (from-to)264-269
Number of pages6
JournalJournal of Clinical Sleep Medicine
Volume6
Issue number3
StatePublished - Jun 15 2010

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Sleep Apnea Syndromes
Social Class
Mothers
Pregnancy
Smoking
Population Control
Gestational Diabetes
Polysomnography
Maternal Age
Child Development
Nervous System
Physical Examination
Weight Gain
History
Hypertension

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Neurology
  • Clinical Neurology

Cite this

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title = "Prenatal and perinatal complications: Is it the link between race and SES and childhood sleep disordered breathing?",
abstract = "Study Objectives: Recent evidence has suggested that low socioeconomic status (SES), race, prematurity, and maternal smoking during pregnancy are associated with childhood sleep disordered breathing (SDB). We investigated (1) the association of SDB with a wide range of risk factors, including prenatal and perinatal complications; (2) the association of these complications with SES and race; and (3) the association of SDB with developmental milestones. Methods: Six hundred thirteen school-aged children (105 clinically referred and 508 community control subjects) underwent overnight polysomnography and had a complete history and physical examination. A comprehensive child development questionnaire was completed by a parent. We compared clinically referred children with SDB to population-based control children without SDB from The Penn State Children's Cohort. Results: Maternal smoking during pregnancy; maternal age and weight gain during pregnancy; prenatal complications, such as maternal high blood pressure and gestational diabetes; perinatal complications related to prematurity; delayed motor milestones; race and SES were significantly associated with the presence of childhood SDB. Most of the risk factors became nonsignificant when analyses controlled for race and SES. Delayed motor milestones remained significantly associated with SDB after controlling for race and SES. Conclusion: These data suggest that there is a significant association between children who experience prenatal or perinatal distress and the development of moderate to severe childhood SDB. SES and race may be mediating the impact on SDB through increased prenatal and perinatal risks. The significant delay in motor milestones suggests that prenatal and perinatal distress may result in neurologic insult, which could influence the development of SDB in later childhood.",
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Prenatal and perinatal complications : Is it the link between race and SES and childhood sleep disordered breathing? / Calhoun, Susan; Vgontzas, Alexandros; Mayes, Susan; Tsaoussoglou, Marina; Sauder, Katherine; Mahr, Fauzia; Karippot, Anoop; Wisner, Krista; Bixler, Edward.

In: Journal of Clinical Sleep Medicine, Vol. 6, No. 3, 15.06.2010, p. 264-269.

Research output: Contribution to journalArticle

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T2 - Is it the link between race and SES and childhood sleep disordered breathing?

AU - Calhoun, Susan

AU - Vgontzas, Alexandros

AU - Mayes, Susan

AU - Tsaoussoglou, Marina

AU - Sauder, Katherine

AU - Mahr, Fauzia

AU - Karippot, Anoop

AU - Wisner, Krista

AU - Bixler, Edward

PY - 2010/6/15

Y1 - 2010/6/15

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