Prenatal diagnosis of duchenne muscular dystrophy: failure of amniotic fluid and maternal serum Nτ-methylhistidine analyses to detect affected fetuses

Steven J. Wassner; Jeanne B. Li; Roger L. Ladda; Robert P. Lorenz; Alan E.H. Emery

doi:10.1016/0002-9378(82)90657-3

Prenatal diagnosis of duchenne muscular dystrophy: failure of amniotic fluid and maternal serum N^τ-methylhistidine analyses to detect affected fetuses

Steven J. Wassner, Jeanne B. Li, Roger L. Ladda, Robert P. Lorenz, Alan E.H. Emery

Department of Pediatrics

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

N^τ-Methylhistidine (MH) and creatinine levels were determined in amniotic fluid and maternal serum from 81 women undergoing midtrimester amniocentesis for reasons other than the diagnosis of neuromuscular disease. Samples were also examined in three pregnancies with male fetuses who were subsequently found to have Duchenne muscular dystrophy (DMD). Between 16 and 20 weeks' gestation, amniotic fluid and maternal serum MH levels averaged 3.22 and 1.94 μmoles/L, respectively. No significant differences were found between the control and affected fetuses for MH and creatinine levels or for MH/creatinine ratios from amniotic fluid or maternal serum. Determination of amniotic fluid MH level thus has no apparent value in the prenatal diagnosis of DMD.

Original language	English (US)
Pages (from-to)	216-219
Number of pages	4
Journal	American journal of obstetrics and gynecology
Volume	143
Issue number	2
DOIs	https://doi.org/10.1016/0002-9378(82)90657-3
State	Published - May 15 1982

All Science Journal Classification (ASJC) codes

Obstetrics and Gynecology

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@article{897c5ca7ec094373899f3a2858ce6cd1,

title = "Prenatal diagnosis of duchenne muscular dystrophy: failure of amniotic fluid and maternal serum Nτ-methylhistidine analyses to detect affected fetuses",

abstract = "Nτ-Methylhistidine (MH) and creatinine levels were determined in amniotic fluid and maternal serum from 81 women undergoing midtrimester amniocentesis for reasons other than the diagnosis of neuromuscular disease. Samples were also examined in three pregnancies with male fetuses who were subsequently found to have Duchenne muscular dystrophy (DMD). Between 16 and 20 weeks' gestation, amniotic fluid and maternal serum MH levels averaged 3.22 and 1.94 μmoles/L, respectively. No significant differences were found between the control and affected fetuses for MH and creatinine levels or for MH/creatinine ratios from amniotic fluid or maternal serum. Determination of amniotic fluid MH level thus has no apparent value in the prenatal diagnosis of DMD.",

author = "Wassner, {Steven J.} and Li, {Jeanne B.} and Ladda, {Roger L.} and Lorenz, {Robert P.} and Emery, {Alan E.H.}",

note = "Funding Information: Supported in part by g-rants from the Muscular Dystrophy Association of America and the National Institutes of Health (AM 24061); by a project grant, Genetic Diseases Screening and Testing, funded by the Department oj Health, Education and Welfare; by the National Foundation-March of Dimes Medical Service Contract C-290: and by Muscular Dystrophy Group of Great Britain.",

year = "1982",

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day = "15",

doi = "10.1016/0002-9378(82)90657-3",

language = "English (US)",

volume = "143",

pages = "216--219",

journal = "American Journal of Obstetrics and Gynecology",

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Prenatal diagnosis of duchenne muscular dystrophy : failure of amniotic fluid and maternal serum N^τ-methylhistidine analyses to detect affected fetuses. / Wassner, Steven J.; Li, Jeanne B.; Ladda, Roger L. et al.

In: American journal of obstetrics and gynecology, Vol. 143, No. 2, 15.05.1982, p. 216-219.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Prenatal diagnosis of duchenne muscular dystrophy

T2 - failure of amniotic fluid and maternal serum Nτ-methylhistidine analyses to detect affected fetuses

AU - Wassner, Steven J.

AU - Li, Jeanne B.

AU - Ladda, Roger L.

AU - Lorenz, Robert P.

AU - Emery, Alan E.H.

N1 - Funding Information: Supported in part by g-rants from the Muscular Dystrophy Association of America and the National Institutes of Health (AM 24061); by a project grant, Genetic Diseases Screening and Testing, funded by the Department oj Health, Education and Welfare; by the National Foundation-March of Dimes Medical Service Contract C-290: and by Muscular Dystrophy Group of Great Britain.

PY - 1982/5/15

Y1 - 1982/5/15

N2 - Nτ-Methylhistidine (MH) and creatinine levels were determined in amniotic fluid and maternal serum from 81 women undergoing midtrimester amniocentesis for reasons other than the diagnosis of neuromuscular disease. Samples were also examined in three pregnancies with male fetuses who were subsequently found to have Duchenne muscular dystrophy (DMD). Between 16 and 20 weeks' gestation, amniotic fluid and maternal serum MH levels averaged 3.22 and 1.94 μmoles/L, respectively. No significant differences were found between the control and affected fetuses for MH and creatinine levels or for MH/creatinine ratios from amniotic fluid or maternal serum. Determination of amniotic fluid MH level thus has no apparent value in the prenatal diagnosis of DMD.

AB - Nτ-Methylhistidine (MH) and creatinine levels were determined in amniotic fluid and maternal serum from 81 women undergoing midtrimester amniocentesis for reasons other than the diagnosis of neuromuscular disease. Samples were also examined in three pregnancies with male fetuses who were subsequently found to have Duchenne muscular dystrophy (DMD). Between 16 and 20 weeks' gestation, amniotic fluid and maternal serum MH levels averaged 3.22 and 1.94 μmoles/L, respectively. No significant differences were found between the control and affected fetuses for MH and creatinine levels or for MH/creatinine ratios from amniotic fluid or maternal serum. Determination of amniotic fluid MH level thus has no apparent value in the prenatal diagnosis of DMD.

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Prenatal diagnosis of duchenne muscular dystrophy: failure of amniotic fluid and maternal serum N^τ-methylhistidine analyses to detect affected fetuses

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