Prenatal diagnosis of duchenne muscular dystrophy

failure of amniotic fluid and maternal serum Nτ-methylhistidine analyses to detect affected fetuses

Steven Wassner, Jeanne B. Li, Roger Ladda, Robert P. Lorenz, Alan E.H. Emery

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Nτ-Methylhistidine (MH) and creatinine levels were determined in amniotic fluid and maternal serum from 81 women undergoing midtrimester amniocentesis for reasons other than the diagnosis of neuromuscular disease. Samples were also examined in three pregnancies with male fetuses who were subsequently found to have Duchenne muscular dystrophy (DMD). Between 16 and 20 weeks' gestation, amniotic fluid and maternal serum MH levels averaged 3.22 and 1.94 μmoles/L, respectively. No significant differences were found between the control and affected fetuses for MH and creatinine levels or for MH/creatinine ratios from amniotic fluid or maternal serum. Determination of amniotic fluid MH level thus has no apparent value in the prenatal diagnosis of DMD.

Original languageEnglish (US)
Pages (from-to)216-219
Number of pages4
JournalAmerican journal of obstetrics and gynecology
Volume143
Issue number2
DOIs
StatePublished - May 15 1982

Fingerprint

Methylhistidines
Duchenne Muscular Dystrophy
Amniotic Fluid
Prenatal Diagnosis
Fetus
Mothers
Creatinine
Serum
Pregnancy
Neuromuscular Diseases
Amniocentesis
Second Pregnancy Trimester

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

@article{897c5ca7ec094373899f3a2858ce6cd1,
title = "Prenatal diagnosis of duchenne muscular dystrophy: failure of amniotic fluid and maternal serum Nτ-methylhistidine analyses to detect affected fetuses",
abstract = "Nτ-Methylhistidine (MH) and creatinine levels were determined in amniotic fluid and maternal serum from 81 women undergoing midtrimester amniocentesis for reasons other than the diagnosis of neuromuscular disease. Samples were also examined in three pregnancies with male fetuses who were subsequently found to have Duchenne muscular dystrophy (DMD). Between 16 and 20 weeks' gestation, amniotic fluid and maternal serum MH levels averaged 3.22 and 1.94 μmoles/L, respectively. No significant differences were found between the control and affected fetuses for MH and creatinine levels or for MH/creatinine ratios from amniotic fluid or maternal serum. Determination of amniotic fluid MH level thus has no apparent value in the prenatal diagnosis of DMD.",
author = "Steven Wassner and Li, {Jeanne B.} and Roger Ladda and Lorenz, {Robert P.} and Emery, {Alan E.H.}",
year = "1982",
month = "5",
day = "15",
doi = "10.1016/0002-9378(82)90657-3",
language = "English (US)",
volume = "143",
pages = "216--219",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "2",

}

Prenatal diagnosis of duchenne muscular dystrophy : failure of amniotic fluid and maternal serum Nτ-methylhistidine analyses to detect affected fetuses. / Wassner, Steven; Li, Jeanne B.; Ladda, Roger; Lorenz, Robert P.; Emery, Alan E.H.

In: American journal of obstetrics and gynecology, Vol. 143, No. 2, 15.05.1982, p. 216-219.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prenatal diagnosis of duchenne muscular dystrophy

T2 - failure of amniotic fluid and maternal serum Nτ-methylhistidine analyses to detect affected fetuses

AU - Wassner, Steven

AU - Li, Jeanne B.

AU - Ladda, Roger

AU - Lorenz, Robert P.

AU - Emery, Alan E.H.

PY - 1982/5/15

Y1 - 1982/5/15

N2 - Nτ-Methylhistidine (MH) and creatinine levels were determined in amniotic fluid and maternal serum from 81 women undergoing midtrimester amniocentesis for reasons other than the diagnosis of neuromuscular disease. Samples were also examined in three pregnancies with male fetuses who were subsequently found to have Duchenne muscular dystrophy (DMD). Between 16 and 20 weeks' gestation, amniotic fluid and maternal serum MH levels averaged 3.22 and 1.94 μmoles/L, respectively. No significant differences were found between the control and affected fetuses for MH and creatinine levels or for MH/creatinine ratios from amniotic fluid or maternal serum. Determination of amniotic fluid MH level thus has no apparent value in the prenatal diagnosis of DMD.

AB - Nτ-Methylhistidine (MH) and creatinine levels were determined in amniotic fluid and maternal serum from 81 women undergoing midtrimester amniocentesis for reasons other than the diagnosis of neuromuscular disease. Samples were also examined in three pregnancies with male fetuses who were subsequently found to have Duchenne muscular dystrophy (DMD). Between 16 and 20 weeks' gestation, amniotic fluid and maternal serum MH levels averaged 3.22 and 1.94 μmoles/L, respectively. No significant differences were found between the control and affected fetuses for MH and creatinine levels or for MH/creatinine ratios from amniotic fluid or maternal serum. Determination of amniotic fluid MH level thus has no apparent value in the prenatal diagnosis of DMD.

UR - http://www.scopus.com/inward/record.url?scp=0020075820&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020075820&partnerID=8YFLogxK

U2 - 10.1016/0002-9378(82)90657-3

DO - 10.1016/0002-9378(82)90657-3

M3 - Article

VL - 143

SP - 216

EP - 219

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 2

ER -