The multi-metal oxide Ti-Ce-Al-Ag-O with high surface area was prepared by co-precipitation method. The sulfur adsorption capacity, selectivity and regenerability of Ti-Ce-Al-Ag-O were evaluated and compared with Ti-Ce-O, Ti-Ce-Al-O and commercial CoO-MoO3/Al2O3 using model fuel and real jet fuel JP-5 in a batch system at room temperature under atmospheric pressure. The results indicate that Ti-Ce-Al-Ag-O adsorbent has higher sulfur adsorption capacity than that of Ti-Ce-Al-O and commercial CoO-MoO3/Al2O3. The sulfur adsorption capacity of Ti-Ce-Al-Ag-O for real jet fuel JP-5 is 7.5 mg-S/g-Ads., which is 226% higher than that of CoO-MoO3/Al2O3. Ti-Ce-Al-Ag-O also has better oxidative regenerability and can be regenerated in air. The present study implies that the multi-metal oxide Ti-Ce-Al-Ag-O is a promising air-oxidation regenerable adsorbent in industrial application.