Preparation of prostaglandin E2 vaginal gel for preinduction ripening of the cervix

Robert P. Lorenz, Laurence Demers

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Low dose prostaglandin E2 (PGE2) vaginal gel has been shown to be an effective method for preinduction ripening of the cervix. A method for preparation of this gel from commercially available reagents is described. A twenty milligram PGE2 vaginal suppository (Prostin, Upjohn) is added to 100 cc's of hydroxyethyl cellulose gel (K-Y) Jelly, Johnson and Johnson), heated to 85°C. Samples of this preparation were stored at a 4° Centigrade (C) or 28° C for one, six, or twenty-four hours. After storage, analysis by radioimmunoassay demonstrated there was no appreciable decrease in concentration of PGE2. A clinical useful prostaglandin E2 vaginal gel may be prepared from commercially available reagents under the conditions described.

Original languageEnglish (US)
Pages (from-to)47-53
Number of pages7
JournalProstaglandins, Leukotrienes and Medicine
Volume14
Issue number1
DOIs
StatePublished - Jan 1 1984

Fingerprint

Foams and Jellies Vaginal Creams
Dinoprostone
Cervix Uteri
Gels
Suppositories
Cellulose
Radioimmunoassay

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology

Cite this

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abstract = "Low dose prostaglandin E2 (PGE2) vaginal gel has been shown to be an effective method for preinduction ripening of the cervix. A method for preparation of this gel from commercially available reagents is described. A twenty milligram PGE2 vaginal suppository (Prostin, Upjohn) is added to 100 cc's of hydroxyethyl cellulose gel (K-Y) Jelly, Johnson and Johnson), heated to 85°C. Samples of this preparation were stored at a 4° Centigrade (C) or 28° C for one, six, or twenty-four hours. After storage, analysis by radioimmunoassay demonstrated there was no appreciable decrease in concentration of PGE2. A clinical useful prostaglandin E2 vaginal gel may be prepared from commercially available reagents under the conditions described.",
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Preparation of prostaglandin E2 vaginal gel for preinduction ripening of the cervix. / Lorenz, Robert P.; Demers, Laurence.

In: Prostaglandins, Leukotrienes and Medicine, Vol. 14, No. 1, 01.01.1984, p. 47-53.

Research output: Contribution to journalArticle

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