Low dose prostaglandin E2 (PGE2) vaginal gel has been shown to be an effective method for preinduction ripening of the cervix. A method for preparation of this gel from commercially available reagents is described. A twenty milligram PGE2 vaginal suppository (Prostin, Upjohn) is added to 100 cc's of hydroxyethyl cellulose gel (K-Y) Jelly, Johnson and Johnson), heated to 85°C. Samples of this preparation were stored at a 4° Centigrade (C) or 28° C for one, six, or twenty-four hours. After storage, analysis by radioimmunoassay demonstrated there was no appreciable decrease in concentration of PGE2. A clinical useful prostaglandin E2 vaginal gel may be prepared from commercially available reagents under the conditions described.
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