Preparation of quaternized organic-inorganic hybrid brush polyphosphazene-co-poly[2-(dimethylamino)ethyl methacrylate] electrospun fibers and their antibacterial properties

Xiao Liu, Hua Zhang, Zhicheng Tian, Ayusman Sen, Harry R. Allcock

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Densely grafted star- and comb-shaped molecular brushes composed of poly[2-(dimethylamino)ethyl methacrylate] were prepared via atom transfer radical polymerization (ATRP) using either cyclotriphosphazenes or polyphosphazenes as initiators. The grafting conditions were optimized in order to obtain well controlled brush structures. The kinetics of the reactions were first-order with respect to the monomer concentration in both cyclotriphosphazene and polyphosphazene systems. The resultant star- and comb-shaped brushes were quaternized with iodomethane, iodobutane, iodoheptane, iododecane and iodododecane, and the products were characterized by NMR, gel permeation chromatography (GPC) and differential scanning calorimetry (DSC). Electrospinning of the quaternized brushes gave rise to microfibers with diameters in range of 700 nm to 1.1 μm, evidenced by scanning electron microscopy (SEM). The antibacterial activity of the quaternized brush species in both aqueous solution and as fibrous solids against Escherichia coli (E. coli) has been evaluated. In aqueous solution, star-shaped brushes quaternized with iodoheptane showed the best antibacterial effect, with a minimum inhibitory concentration (MIC) as low as 250 μg mL -1. In the fibrous solid state, more than 99% of E. coli were killed within 2 h after contacting 100 mg of microfibers electrospun from the star-shaped brush polymers quaternized with either iododecane or iodododecane.

Original languageEnglish (US)
Pages (from-to)2082-2091
Number of pages10
JournalPolymer Chemistry
Volume3
Issue number8
DOIs
StatePublished - Aug 1 2012

Fingerprint

Comb and Wattles
Brushes
Escherichia coli
Fibers
Differential Scanning Calorimetry
Microbial Sensitivity Tests
Stars
Polymerization
Electron Scanning Microscopy
Gel Chromatography
Polymers
Atom transfer radical polymerization
Electrospinning
Gel permeation chromatography
poly(phosphazene)
poly(2-(dimethylamino)ethyl methacrylate)
Differential scanning calorimetry
Monomers
Nuclear magnetic resonance
Scanning electron microscopy

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Polymers and Plastics
  • Organic Chemistry

Cite this

@article{fc6c6c771ae54a179b2ef299a0d0ea53,
title = "Preparation of quaternized organic-inorganic hybrid brush polyphosphazene-co-poly[2-(dimethylamino)ethyl methacrylate] electrospun fibers and their antibacterial properties",
abstract = "Densely grafted star- and comb-shaped molecular brushes composed of poly[2-(dimethylamino)ethyl methacrylate] were prepared via atom transfer radical polymerization (ATRP) using either cyclotriphosphazenes or polyphosphazenes as initiators. The grafting conditions were optimized in order to obtain well controlled brush structures. The kinetics of the reactions were first-order with respect to the monomer concentration in both cyclotriphosphazene and polyphosphazene systems. The resultant star- and comb-shaped brushes were quaternized with iodomethane, iodobutane, iodoheptane, iododecane and iodododecane, and the products were characterized by NMR, gel permeation chromatography (GPC) and differential scanning calorimetry (DSC). Electrospinning of the quaternized brushes gave rise to microfibers with diameters in range of 700 nm to 1.1 μm, evidenced by scanning electron microscopy (SEM). The antibacterial activity of the quaternized brush species in both aqueous solution and as fibrous solids against Escherichia coli (E. coli) has been evaluated. In aqueous solution, star-shaped brushes quaternized with iodoheptane showed the best antibacterial effect, with a minimum inhibitory concentration (MIC) as low as 250 μg mL -1. In the fibrous solid state, more than 99{\%} of E. coli were killed within 2 h after contacting 100 mg of microfibers electrospun from the star-shaped brush polymers quaternized with either iododecane or iodododecane.",
author = "Xiao Liu and Hua Zhang and Zhicheng Tian and Ayusman Sen and Allcock, {Harry R.}",
year = "2012",
month = "8",
day = "1",
doi = "10.1039/c2py20170d",
language = "English (US)",
volume = "3",
pages = "2082--2091",
journal = "Polymer Chemistry",
issn = "1759-9954",
publisher = "Royal Society of Chemistry",
number = "8",

}

TY - JOUR

T1 - Preparation of quaternized organic-inorganic hybrid brush polyphosphazene-co-poly[2-(dimethylamino)ethyl methacrylate] electrospun fibers and their antibacterial properties

AU - Liu, Xiao

AU - Zhang, Hua

AU - Tian, Zhicheng

AU - Sen, Ayusman

AU - Allcock, Harry R.

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Densely grafted star- and comb-shaped molecular brushes composed of poly[2-(dimethylamino)ethyl methacrylate] were prepared via atom transfer radical polymerization (ATRP) using either cyclotriphosphazenes or polyphosphazenes as initiators. The grafting conditions were optimized in order to obtain well controlled brush structures. The kinetics of the reactions were first-order with respect to the monomer concentration in both cyclotriphosphazene and polyphosphazene systems. The resultant star- and comb-shaped brushes were quaternized with iodomethane, iodobutane, iodoheptane, iododecane and iodododecane, and the products were characterized by NMR, gel permeation chromatography (GPC) and differential scanning calorimetry (DSC). Electrospinning of the quaternized brushes gave rise to microfibers with diameters in range of 700 nm to 1.1 μm, evidenced by scanning electron microscopy (SEM). The antibacterial activity of the quaternized brush species in both aqueous solution and as fibrous solids against Escherichia coli (E. coli) has been evaluated. In aqueous solution, star-shaped brushes quaternized with iodoheptane showed the best antibacterial effect, with a minimum inhibitory concentration (MIC) as low as 250 μg mL -1. In the fibrous solid state, more than 99% of E. coli were killed within 2 h after contacting 100 mg of microfibers electrospun from the star-shaped brush polymers quaternized with either iododecane or iodododecane.

AB - Densely grafted star- and comb-shaped molecular brushes composed of poly[2-(dimethylamino)ethyl methacrylate] were prepared via atom transfer radical polymerization (ATRP) using either cyclotriphosphazenes or polyphosphazenes as initiators. The grafting conditions were optimized in order to obtain well controlled brush structures. The kinetics of the reactions were first-order with respect to the monomer concentration in both cyclotriphosphazene and polyphosphazene systems. The resultant star- and comb-shaped brushes were quaternized with iodomethane, iodobutane, iodoheptane, iododecane and iodododecane, and the products were characterized by NMR, gel permeation chromatography (GPC) and differential scanning calorimetry (DSC). Electrospinning of the quaternized brushes gave rise to microfibers with diameters in range of 700 nm to 1.1 μm, evidenced by scanning electron microscopy (SEM). The antibacterial activity of the quaternized brush species in both aqueous solution and as fibrous solids against Escherichia coli (E. coli) has been evaluated. In aqueous solution, star-shaped brushes quaternized with iodoheptane showed the best antibacterial effect, with a minimum inhibitory concentration (MIC) as low as 250 μg mL -1. In the fibrous solid state, more than 99% of E. coli were killed within 2 h after contacting 100 mg of microfibers electrospun from the star-shaped brush polymers quaternized with either iododecane or iodododecane.

UR - http://www.scopus.com/inward/record.url?scp=84868676196&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868676196&partnerID=8YFLogxK

U2 - 10.1039/c2py20170d

DO - 10.1039/c2py20170d

M3 - Article

AN - SCOPUS:84868676196

VL - 3

SP - 2082

EP - 2091

JO - Polymer Chemistry

JF - Polymer Chemistry

SN - 1759-9954

IS - 8

ER -