Preparative-Scale Separation of Enantiomers Using Intercalated -Zirconium Phosphate

Maurie E. Garcia, Jacqueline L. Naffin, Nanlin Deng, Thomas E. Mallouk

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

New lamellar compounds that have potential utility in preparative-scale enantiomeric separations were developed by combining principles from solid-state and molecular hostguest chemistry. Intercalation of α-zirconium phosphate (α-ZrP) by a cationic chiral -acceptor produces a solid that selectively binds one enantiomer of a π-donor analyte from a racemic solution. Both crystalline and semicrystalline α-ZrP were investigated in order to determine whether crystallinity and particle size have an effect on this process. Under favorable conditions, preparative-scale separations can be achieved in a batchwise process by means of multiple passes through the intercalated solid. Even if scaled up for singlepass enantioseparation, these solids provide over 30 times the separation capacity per gram relative to brush-type chiral selectors immobilized on chromatographic silica. The intercalated solids were characterized by UV-visible and FT-IR spectroscopies and by powder X-ray diffraction. A dramatic concentration effect is seen in the enantioselective binding; at low concentration of the enantiomer which forms a complex with the intercalated chiral selector there is essentially no binding, while above 150 mM the intercalated chiral host-guest complex is formed almost quantitatively. The structural nature of this concentration dependence is discussed.

Original languageEnglish (US)
Pages (from-to)1968-1973
Number of pages6
JournalChemistry of Materials
Volume7
Issue number10
DOIs
StatePublished - Jan 1 1995

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Enantiomers
Zirconium
Phosphates
Brushes
Intercalation
Silicon Dioxide
X ray powder diffraction
Infrared spectroscopy
Particle size
Silica
zirconium phosphate
Crystalline materials

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)
  • Materials Chemistry

Cite this

Garcia, Maurie E. ; Naffin, Jacqueline L. ; Deng, Nanlin ; Mallouk, Thomas E. / Preparative-Scale Separation of Enantiomers Using Intercalated -Zirconium Phosphate. In: Chemistry of Materials. 1995 ; Vol. 7, No. 10. pp. 1968-1973.
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Preparative-Scale Separation of Enantiomers Using Intercalated -Zirconium Phosphate. / Garcia, Maurie E.; Naffin, Jacqueline L.; Deng, Nanlin; Mallouk, Thomas E.

In: Chemistry of Materials, Vol. 7, No. 10, 01.01.1995, p. 1968-1973.

Research output: Contribution to journalArticle

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