Presentation and initial clinical course in patients with chronic inflammatory demyelinating polyradiculoneuropathy: Comparison of patients without and with monoclonal gammopathy

Zachary Simmons, James W. Albers, Mark B. Bromberg, Eva L. Feldman

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) may occur in association with a monoclonal gammopathy of undetermined significance (MGUS) or a variety of other systemic illnesses. It is not known if the clinical features of CIDP are altered by the presence of an MGUS. We compared demographic features, clinical presentation, improvement and outcome after initial treatment, and electrodiagnostic features of a group of 77 patients with idiopathic CIDP (CIDP-I, no associated systemic illness) with 26 patients with CIDP in whom an MGUS was found during evaluation of the neuropathy (CIDP-MGUS). Patients with CIDP-MGUS had, on average, a more indolent course and less severe weakness than patients with CIDP-I, despite similar motor conduction studies. CIDP-MGUS patients also demonstrated less functional impairment, more frequent sensory loss, and more abnormal sensory conduction studies than patients with CIDP-I. Because of the greater improvement of CIDP-I patients with treatment, both groups had similar outcomes from their initial episodes of weakness. Subgroup analysis of CIDP-MGUS patients did not demonstrate differences between groups with IgM and IgG or IgA gammopathies.

Original languageEnglish (US)
Pages (from-to)2202-2209
Number of pages8
JournalNeurology
Volume43
Issue number11
StatePublished - Nov 1993

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Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Paraproteinemias
Monoclonal Gammopathy of Undetermined Significance
Immunoglobulin A
Immunoglobulin M

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

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Presentation and initial clinical course in patients with chronic inflammatory demyelinating polyradiculoneuropathy : Comparison of patients without and with monoclonal gammopathy. / Simmons, Zachary; Albers, James W.; Bromberg, Mark B.; Feldman, Eva L.

In: Neurology, Vol. 43, No. 11, 11.1993, p. 2202-2209.

Research output: Contribution to journalArticle

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