Pressor responses to stimulation of non-NMDA receptors in the superficial laminae of the cat spinal cord

Michael K.C. Wong, Janeen M. Hill, Marc Kaufman

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Microinjection ofl-glutamate (109 mM; 12-18nl) or AMPA (150-300 μM; 12 nl) into the superficial laminae of the L7 dorsal horn of decerebrate or chloralose anesthetized cats significantly increased mean arterial pressure. In contrast, microinjection of NMDA (300 μM; 12 nl) had no effect on mean arterial pressure. The pressor response tol-glutamate microinjection was blocked by prior microinjection of CNQX, an antagonist to non-NMDA receptors, but not by AP-5, an antagonist to NMDA receptors. We conclude that stimulation of non-NMDA receptors in the superficial laminae of the lumbar dorsal horn increases arterial blood pressure.

Original languageEnglish (US)
Pages (from-to)149-152
Number of pages4
JournalBrain research
Volume683
Issue number1
DOIs
StatePublished - Jun 12 1995

Fingerprint

Microinjections
Spinal Cord
Cats
Arterial Pressure
Glutamic Acid
6-Cyano-7-nitroquinoxaline-2,3-dione
Chloralose
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
N-Methylaspartate
N-Methyl-D-Aspartate Receptors
Spinal Cord Dorsal Horn

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

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abstract = "Microinjection ofl-glutamate (109 mM; 12-18nl) or AMPA (150-300 μM; 12 nl) into the superficial laminae of the L7 dorsal horn of decerebrate or chloralose anesthetized cats significantly increased mean arterial pressure. In contrast, microinjection of NMDA (300 μM; 12 nl) had no effect on mean arterial pressure. The pressor response tol-glutamate microinjection was blocked by prior microinjection of CNQX, an antagonist to non-NMDA receptors, but not by AP-5, an antagonist to NMDA receptors. We conclude that stimulation of non-NMDA receptors in the superficial laminae of the lumbar dorsal horn increases arterial blood pressure.",
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Pressor responses to stimulation of non-NMDA receptors in the superficial laminae of the cat spinal cord. / Wong, Michael K.C.; Hill, Janeen M.; Kaufman, Marc.

In: Brain research, Vol. 683, No. 1, 12.06.1995, p. 149-152.

Research output: Contribution to journalArticle

TY - JOUR

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