Pressure‐flow relationships in the peripheral circulation of the dog with practolol

Jerry Franklin Green, John D. Moore, Edward S. Attix, Robert Zelis

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

1. The influence of practolol (a proposed β1‐adrenoreceptor antagonist) upon the pressure‐flow relationships in the peripheral circulation was studied in eight anaesthetized dogs during right heart by‐pass procedures. 2. Practolol (1 mg/kg) produced a significant increase in the resistance to venous return which resulted in a significant fall in venous return. 3. There was no significant change in arterial resistance. 4. This study suggests that practolol should not be classified as an exclusive cardioselective β‐adrenoreceptor antagonist.

Original languageEnglish (US)
Pages (from-to)17-21
Number of pages5
JournalClinical and Experimental Pharmacology and Physiology
Volume2
Issue number1
DOIs
StatePublished - Jan 1 1975

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)

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