Presumptive spontaneous lysosomal storage-like disease in a Crl:CD1(ICR) mouse

Krista M. Hernon, Tiffany Whitcomb, Lori Davis, Timothy Cooper

Research output: Contribution to journalArticle

Abstract

A clinically unremarkable 4.5-mo-old female Crl:CD1(ICR) VAF/Elite mouse was euthanized for scheduled sentinel processing. Gross necropsy findings included significant hepatosplenomegaly and visceral lymphadenomegaly, resulting in a preliminary gross diagnosis of lymphoma. Histology revealed florid accumulations of large, 'foamy' macrophages present in the bone marrow, small intestines, and viscera including liver, spleen, lymph nodes, thymus, uterus, and ovaries. The cytoplasm of these cells was abundant, stained pale blue with Wright-Giemsa and was periodic acid-Schiff positive. Given these characteristic gross and histologic findings, a spontaneous lysosomal storage-like disease was diagnosed in this mouse. Cholesterol ester storage disease is likely, because of the visceral involvement with sparing of the CNS, but could not be diagnosed definitively. To our knowledge, this report is the first to describe a case of spontaneous lysosomal storage disease in an outbred mouse of the CD1(ICR) background.

Original languageEnglish (US)
Pages (from-to)28-33
Number of pages6
JournalComparative Medicine
Volume67
Issue number1
StatePublished - Feb 1 2017

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Lysosomal Storage Diseases
Inbred ICR Mouse
Cholesterol Ester Storage Disease
Periodic Acid
Viscera
mice
Thymus Gland
Small Intestine
Uterus
Thymus
Ovary
Lymphoma
Histology
Cytoplasm
Spleen
cholesteryl esters
Cholesterol Esters
Macrophages
Lymph Nodes
Bone Marrow

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

Cite this

Hernon, Krista M. ; Whitcomb, Tiffany ; Davis, Lori ; Cooper, Timothy. / Presumptive spontaneous lysosomal storage-like disease in a Crl:CD1(ICR) mouse. In: Comparative Medicine. 2017 ; Vol. 67, No. 1. pp. 28-33.
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Presumptive spontaneous lysosomal storage-like disease in a Crl:CD1(ICR) mouse. / Hernon, Krista M.; Whitcomb, Tiffany; Davis, Lori; Cooper, Timothy.

In: Comparative Medicine, Vol. 67, No. 1, 01.02.2017, p. 28-33.

Research output: Contribution to journalArticle

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AB - A clinically unremarkable 4.5-mo-old female Crl:CD1(ICR) VAF/Elite mouse was euthanized for scheduled sentinel processing. Gross necropsy findings included significant hepatosplenomegaly and visceral lymphadenomegaly, resulting in a preliminary gross diagnosis of lymphoma. Histology revealed florid accumulations of large, 'foamy' macrophages present in the bone marrow, small intestines, and viscera including liver, spleen, lymph nodes, thymus, uterus, and ovaries. The cytoplasm of these cells was abundant, stained pale blue with Wright-Giemsa and was periodic acid-Schiff positive. Given these characteristic gross and histologic findings, a spontaneous lysosomal storage-like disease was diagnosed in this mouse. Cholesterol ester storage disease is likely, because of the visceral involvement with sparing of the CNS, but could not be diagnosed definitively. To our knowledge, this report is the first to describe a case of spontaneous lysosomal storage disease in an outbred mouse of the CD1(ICR) background.

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