Prevalence and trend of allergen sensitization in patients referred for patch testing with a final diagnosis of psoriasis: North American Contact Dermatitis Group data, 2001-2016

Jonathan I. Silverberg, Alexander Hou, Joel G. DeKoven, Erin M. Warshaw, Howard I. Maibach, Amber R. Atwater, Donald V. Belsito, Kathryn A. Zug, James S. Taylor, Denis Sasseville, Anthony F. Fransway, Vincent A. DeLeo, Melanie D. Pratt, Margo J. Reeder, Joseph F. Fowler, Matthew J. Zirwas, James G. Marks, Cory A. Dunnick, Marie Claude Houle

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Little is known about the relationship between psoriasis and allergic contact dermatitis (ACD). Objective: To examine the associations with ACD, related clinical characteristics, and common positive and clinically relevant allergens of patients with a final diagnosis of psoriasis who were referred for patch testing. Methods: Retrospective analysis of 38 723 patients from the North American Contact Dermatitis Group. Results: Patients with a final diagnosis of psoriasis had lower proportions of ACD than those without psoriasis (32.7% vs 57.8%). In multivariable logistic regression models, psoriasis was inversely associated with female sex, Black or Asian race, and history of atopic dermatitis and hay fever. Patients with a final diagnosis of psoriasis were less likely to have one or more positive allergic patch-test reactions or to have a current clinically relevant patch-test reaction to the majority of the most commonly positive and/or relevant allergens. The most clinically relevant allergens included nickel sulfate, methylisothiazolinone, and fragrance mix I. Conclusion: Approximately one-third of patients who were referred for patch testing with a final diagnosis of psoriasis were also diagnosed with ACD. In select patients with suspected psoriasis who also have a clinical presentation suggestive of ACD, patch testing may be helpful.

Original languageEnglish (US)
Pages (from-to)435-445
Number of pages11
JournalContact Dermatitis
Volume85
Issue number4
DOIs
StatePublished - Oct 2021

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Dermatology

Fingerprint

Dive into the research topics of 'Prevalence and trend of allergen sensitization in patients referred for patch testing with a final diagnosis of psoriasis: North American Contact Dermatitis Group data, 2001-2016'. Together they form a unique fingerprint.

Cite this