Prevalence of Bovine Tuberculosis in India: A systematic review and meta-analysis

Sreenidhi Srinivasan, Laurel Easterling, Bipin Rimal, Xiaoyue Maggie Niu, Andrew J.K. Conlan, Patrick Dudas, Vivek Kapur

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Bovine tuberculosis (bTB) is a chronic disease of cattle that impacts productivity and represents a major public health threat. Despite the considerable economic costs and zoonotic risk consequences associated with the disease, accurate estimates of bTB prevalence are lacking in many countries, including India, where national control programmes are not yet implemented and the disease is considered endemic. To address this critical knowledge gap, we performed a systematic review of the literature and a meta-analysis to estimate bTB prevalence in cattle in India and provide a foundation for the future formulation of rational disease control strategies and the accurate assessment of economic and health impact risks. The literature search was performed in accordance with PRISMA guidelines and identified 285 cross-sectional studies on bTB in cattle in India across four electronic databases and handpicked publications. Of these, 44 articles were included, contributing a total of 82,419 cows and buffaloes across 18 states and one union territory in India. Based on a random-effects (RE) meta-regression model, the analysis revealed a pooled prevalence estimate of 7.3% (95% CI: 5.6, 9.5), indicating that there may be an estimated 21.8 million (95% CI: 16.6, 28.4) infected cattle in India—a population greater than the total number of dairy cows in the United States. The analyses further suggest that production system, species, breed, study location, diagnostic technique, sample size and study period are likely moderators of bTB prevalence in India and need to be considered when developing future disease surveillance and control programmes. Taken together with the projected increase in intensification of dairy production and the subsequent increase in the likelihood of zoonotic transmission, the results of our study suggest that attempts to eliminate tuberculosis from humans will require simultaneous consideration of bTB control in cattle population in countries such as India.

Original languageEnglish (US)
Pages (from-to)1627-1640
Number of pages14
JournalTransboundary and Emerging Diseases
Volume65
Issue number6
DOIs
StatePublished - Dec 2018

Fingerprint

Bovine Tuberculosis
bovine tuberculosis
systematic review
meta-analysis
Meta-Analysis
India
cattle
Zoonoses
disease control
Health Impact Assessment
Economics
economic costs
disease surveillance
Buffaloes
chronic diseases
tuberculosis
cross-sectional studies
Sample Size
diagnostic techniques
Population

All Science Journal Classification (ASJC) codes

  • Immunology and Microbiology(all)
  • veterinary(all)

Cite this

Srinivasan, Sreenidhi ; Easterling, Laurel ; Rimal, Bipin ; Niu, Xiaoyue Maggie ; Conlan, Andrew J.K. ; Dudas, Patrick ; Kapur, Vivek. / Prevalence of Bovine Tuberculosis in India : A systematic review and meta-analysis. In: Transboundary and Emerging Diseases. 2018 ; Vol. 65, No. 6. pp. 1627-1640.
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abstract = "Bovine tuberculosis (bTB) is a chronic disease of cattle that impacts productivity and represents a major public health threat. Despite the considerable economic costs and zoonotic risk consequences associated with the disease, accurate estimates of bTB prevalence are lacking in many countries, including India, where national control programmes are not yet implemented and the disease is considered endemic. To address this critical knowledge gap, we performed a systematic review of the literature and a meta-analysis to estimate bTB prevalence in cattle in India and provide a foundation for the future formulation of rational disease control strategies and the accurate assessment of economic and health impact risks. The literature search was performed in accordance with PRISMA guidelines and identified 285 cross-sectional studies on bTB in cattle in India across four electronic databases and handpicked publications. Of these, 44 articles were included, contributing a total of 82,419 cows and buffaloes across 18 states and one union territory in India. Based on a random-effects (RE) meta-regression model, the analysis revealed a pooled prevalence estimate of 7.3{\%} (95{\%} CI: 5.6, 9.5), indicating that there may be an estimated 21.8 million (95{\%} CI: 16.6, 28.4) infected cattle in India—a population greater than the total number of dairy cows in the United States. The analyses further suggest that production system, species, breed, study location, diagnostic technique, sample size and study period are likely moderators of bTB prevalence in India and need to be considered when developing future disease surveillance and control programmes. Taken together with the projected increase in intensification of dairy production and the subsequent increase in the likelihood of zoonotic transmission, the results of our study suggest that attempts to eliminate tuberculosis from humans will require simultaneous consideration of bTB control in cattle population in countries such as India.",
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Prevalence of Bovine Tuberculosis in India : A systematic review and meta-analysis. / Srinivasan, Sreenidhi; Easterling, Laurel; Rimal, Bipin; Niu, Xiaoyue Maggie; Conlan, Andrew J.K.; Dudas, Patrick; Kapur, Vivek.

In: Transboundary and Emerging Diseases, Vol. 65, No. 6, 12.2018, p. 1627-1640.

Research output: Contribution to journalArticle

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