Prevalence of dural venous sinus stenosis and hypoplasia in a generalized population

Christopher R. Durst, David A. Ornan, Michael A. Reardon, Prachi Mehndiratta, Sugoto Mukherjee, Robert M. Starke, Max Wintermark, Avery Evans, Mary E. Jensen, R. Webster Crowley, John Gaughen, Kenneth Liu

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background and purpose While recent literature has described the prevalence of transverse sinus stenosis in patients with idiopathic intracranial hypertension, tinnitus, and refractory headaches, it is unclear what the prevalence is in the general population. This study evaluates the prevalence of venous sinus stenosis and hypoplasia in the general patient population. Materials and methods 355 of 600 consecutive patients who underwent CT angiography of the head met the inclusion criteria. The diameters of the dural venous sinuses were recorded. Each study was evaluated by a neuroradiologist for the presence of stenoses. Univariate and multivariate statistical analyses were performed by a statistician. Results The prevalence of unilateral transverse sinus stenosis or hypoplasia in a sample of patients representing the general population was 33%, the prevalence of bilateral transverse sinus stenosis was 5%, and the prevalence of unilateral stenosis with contralateral hypoplasia was 1%. A multivariate analysis identified arachnoid granulations as a predictor of stenosis (p<0.001). Gender trended toward significance (p=0.094). Race was not a significant predictor of stenosis (p=0.745). Conclusions The prevalence of bilateral transverse sinus stenosis in the general population is not trivial. These data may be used as a reference for understanding the mechanistic role of stenoses in idiopathic intracranial hypertension, tinnitus, and refractory headaches.

Original languageEnglish (US)
Pages (from-to)1173-1177
Number of pages5
JournalJournal of NeuroInterventional Surgery
Volume8
Issue number11
DOIs
StatePublished - Nov 1 2016

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Pathologic Constriction
Transverse Sinuses
Population
Pseudotumor Cerebri
Tinnitus
Headache
Multivariate Analysis
Arachnoid
Cross-Sectional Studies
Head

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

Durst, C. R., Ornan, D. A., Reardon, M. A., Mehndiratta, P., Mukherjee, S., Starke, R. M., ... Liu, K. (2016). Prevalence of dural venous sinus stenosis and hypoplasia in a generalized population. Journal of NeuroInterventional Surgery, 8(11), 1173-1177. https://doi.org/10.1136/neurintsurg-2015-012147
Durst, Christopher R. ; Ornan, David A. ; Reardon, Michael A. ; Mehndiratta, Prachi ; Mukherjee, Sugoto ; Starke, Robert M. ; Wintermark, Max ; Evans, Avery ; Jensen, Mary E. ; Crowley, R. Webster ; Gaughen, John ; Liu, Kenneth. / Prevalence of dural venous sinus stenosis and hypoplasia in a generalized population. In: Journal of NeuroInterventional Surgery. 2016 ; Vol. 8, No. 11. pp. 1173-1177.
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Durst, CR, Ornan, DA, Reardon, MA, Mehndiratta, P, Mukherjee, S, Starke, RM, Wintermark, M, Evans, A, Jensen, ME, Crowley, RW, Gaughen, J & Liu, K 2016, 'Prevalence of dural venous sinus stenosis and hypoplasia in a generalized population', Journal of NeuroInterventional Surgery, vol. 8, no. 11, pp. 1173-1177. https://doi.org/10.1136/neurintsurg-2015-012147

Prevalence of dural venous sinus stenosis and hypoplasia in a generalized population. / Durst, Christopher R.; Ornan, David A.; Reardon, Michael A.; Mehndiratta, Prachi; Mukherjee, Sugoto; Starke, Robert M.; Wintermark, Max; Evans, Avery; Jensen, Mary E.; Crowley, R. Webster; Gaughen, John; Liu, Kenneth.

In: Journal of NeuroInterventional Surgery, Vol. 8, No. 11, 01.11.2016, p. 1173-1177.

Research output: Contribution to journalArticle

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T1 - Prevalence of dural venous sinus stenosis and hypoplasia in a generalized population

AU - Durst, Christopher R.

AU - Ornan, David A.

AU - Reardon, Michael A.

AU - Mehndiratta, Prachi

AU - Mukherjee, Sugoto

AU - Starke, Robert M.

AU - Wintermark, Max

AU - Evans, Avery

AU - Jensen, Mary E.

AU - Crowley, R. Webster

AU - Gaughen, John

AU - Liu, Kenneth

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Background and purpose While recent literature has described the prevalence of transverse sinus stenosis in patients with idiopathic intracranial hypertension, tinnitus, and refractory headaches, it is unclear what the prevalence is in the general population. This study evaluates the prevalence of venous sinus stenosis and hypoplasia in the general patient population. Materials and methods 355 of 600 consecutive patients who underwent CT angiography of the head met the inclusion criteria. The diameters of the dural venous sinuses were recorded. Each study was evaluated by a neuroradiologist for the presence of stenoses. Univariate and multivariate statistical analyses were performed by a statistician. Results The prevalence of unilateral transverse sinus stenosis or hypoplasia in a sample of patients representing the general population was 33%, the prevalence of bilateral transverse sinus stenosis was 5%, and the prevalence of unilateral stenosis with contralateral hypoplasia was 1%. A multivariate analysis identified arachnoid granulations as a predictor of stenosis (p<0.001). Gender trended toward significance (p=0.094). Race was not a significant predictor of stenosis (p=0.745). Conclusions The prevalence of bilateral transverse sinus stenosis in the general population is not trivial. These data may be used as a reference for understanding the mechanistic role of stenoses in idiopathic intracranial hypertension, tinnitus, and refractory headaches.

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