Prevalence of elevated hemoglobin A 2 measured by the CAPILLARYS system

Zhaohai Yang, Carolyn H. Chaffin, Pattye L. Easley, Beatrice Thigpen, Vishnu V.B. Reddy

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

Hemoglobin (Hb) A 2 electrophoresis has been used for prenatal screening for the ß-thalassemia trait (ßTT). We retrospectively reviewed Hb capillary electrophoresis performed in our laboratory. We found that of the 122 cases showing elevated HbA 2 levels, 79 cases were due to hemoglobinopathies, mostly HbS. Review of the RBC indices suggested that 3 of 36 cases with elevation of HbA 2 in the HbAA-pregnancy group had ßTT and 29 had normal RBC indices; data were not available for 4 patients. Among 7 cases with elevation of HbA 2 in the HbAA-other group, 5 had ßTT and 2 were normal. The number of patients without ßTT but with HbA 2 elevation in the pregnant group was significantly higher than that in the nonpregnant group. When a higher HbA 2 cutoff (3.5%) was used, only 3 pregnant patients without ßTT had HbA 2 elevation, similar to the nonpregnant group. We found that a significant number of pregnant women with mild HbA 2 elevation had no evidence of ßTT, compared with the nonpregnant group.

Original languageEnglish (US)
Pages (from-to)42-48
Number of pages7
JournalAmerican journal of clinical pathology
Volume131
Issue number1
DOIs
StatePublished - Jan 1 2009

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Hemoglobin A
Thalassemia
Hemoglobinopathies
Capillary Electrophoresis
Prenatal Diagnosis
Electrophoresis
Pregnant Women
Hemoglobins
Pregnancy

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Yang, Zhaohai ; Chaffin, Carolyn H. ; Easley, Pattye L. ; Thigpen, Beatrice ; Reddy, Vishnu V.B. / Prevalence of elevated hemoglobin A 2 measured by the CAPILLARYS system. In: American journal of clinical pathology. 2009 ; Vol. 131, No. 1. pp. 42-48.
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abstract = "Hemoglobin (Hb) A 2 electrophoresis has been used for prenatal screening for the {\ss}-thalassemia trait ({\ss}TT). We retrospectively reviewed Hb capillary electrophoresis performed in our laboratory. We found that of the 122 cases showing elevated HbA 2 levels, 79 cases were due to hemoglobinopathies, mostly HbS. Review of the RBC indices suggested that 3 of 36 cases with elevation of HbA 2 in the HbAA-pregnancy group had {\ss}TT and 29 had normal RBC indices; data were not available for 4 patients. Among 7 cases with elevation of HbA 2 in the HbAA-other group, 5 had {\ss}TT and 2 were normal. The number of patients without {\ss}TT but with HbA 2 elevation in the pregnant group was significantly higher than that in the nonpregnant group. When a higher HbA 2 cutoff (3.5{\%}) was used, only 3 pregnant patients without {\ss}TT had HbA 2 elevation, similar to the nonpregnant group. We found that a significant number of pregnant women with mild HbA 2 elevation had no evidence of {\ss}TT, compared with the nonpregnant group.",
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Prevalence of elevated hemoglobin A 2 measured by the CAPILLARYS system. / Yang, Zhaohai; Chaffin, Carolyn H.; Easley, Pattye L.; Thigpen, Beatrice; Reddy, Vishnu V.B.

In: American journal of clinical pathology, Vol. 131, No. 1, 01.01.2009, p. 42-48.

Research output: Contribution to journalReview article

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AU - Yang, Zhaohai

AU - Chaffin, Carolyn H.

AU - Easley, Pattye L.

AU - Thigpen, Beatrice

AU - Reddy, Vishnu V.B.

PY - 2009/1/1

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N2 - Hemoglobin (Hb) A 2 electrophoresis has been used for prenatal screening for the ß-thalassemia trait (ßTT). We retrospectively reviewed Hb capillary electrophoresis performed in our laboratory. We found that of the 122 cases showing elevated HbA 2 levels, 79 cases were due to hemoglobinopathies, mostly HbS. Review of the RBC indices suggested that 3 of 36 cases with elevation of HbA 2 in the HbAA-pregnancy group had ßTT and 29 had normal RBC indices; data were not available for 4 patients. Among 7 cases with elevation of HbA 2 in the HbAA-other group, 5 had ßTT and 2 were normal. The number of patients without ßTT but with HbA 2 elevation in the pregnant group was significantly higher than that in the nonpregnant group. When a higher HbA 2 cutoff (3.5%) was used, only 3 pregnant patients without ßTT had HbA 2 elevation, similar to the nonpregnant group. We found that a significant number of pregnant women with mild HbA 2 elevation had no evidence of ßTT, compared with the nonpregnant group.

AB - Hemoglobin (Hb) A 2 electrophoresis has been used for prenatal screening for the ß-thalassemia trait (ßTT). We retrospectively reviewed Hb capillary electrophoresis performed in our laboratory. We found that of the 122 cases showing elevated HbA 2 levels, 79 cases were due to hemoglobinopathies, mostly HbS. Review of the RBC indices suggested that 3 of 36 cases with elevation of HbA 2 in the HbAA-pregnancy group had ßTT and 29 had normal RBC indices; data were not available for 4 patients. Among 7 cases with elevation of HbA 2 in the HbAA-other group, 5 had ßTT and 2 were normal. The number of patients without ßTT but with HbA 2 elevation in the pregnant group was significantly higher than that in the nonpregnant group. When a higher HbA 2 cutoff (3.5%) was used, only 3 pregnant patients without ßTT had HbA 2 elevation, similar to the nonpregnant group. We found that a significant number of pregnant women with mild HbA 2 elevation had no evidence of ßTT, compared with the nonpregnant group.

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