Prevalence of high-risk HPV and associated risk factors in cases of cervical carcinoma in Tamil Nadu, India

Krishnakumar Vinodhini, Shanmughapriya Santhanam, Sumathy Sanmugham, Ganesan Senthikumar, Bhudev C. Das, Kalimuthusamy Natarajaseenivasan

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: To assess the prevalence of HPV infection among women with cervical cancer in Tiruchirapalli, Tamil Nadu, India. Methods: A case-control study was conducted with 246 women with cervical cancer and 257 control participants aged between 20 and 70 years. The presence of HPV DNA was determined using the MY09/11 PCR protocol, the GP5+/6+ PCR protocol, and type-specific PCR-based assays. Results: The overall HPV prevalence was 54.9% and HPV 16 was the most prevalent type. The women the most vulnerable for HPV infection were those aged 41 to 60 years. The major contributing risk factors for cervical cancer were having had 3 or more pregnancies (OR 19.2; 95% CI, 10.78-10.16); harboring high-risk HPV DNA (OR 15.3; 95% CI, 9.81-23.8); being a manual worker (OR 14.9; 95% CI, 9.62-23.08); being illiterate (OR 8.28; 95% CI, 5.51-12.43); and having never been screened for cervical dysplasia (OR 6.70; 95% CI, 10.78-34.44). Conclusion: The present report on the overall and type-specific prevalence rates and risk burden of HPV infection in Tamil Nadu confirms that screening and vaccination programs are urgently needed in this state to overcome the burden of HPV-associated cervical cancer.

Original languageEnglish (US)
Pages (from-to)253-256
Number of pages4
JournalInternational Journal of Gynecology and Obstetrics
Volume119
Issue number3
DOIs
StatePublished - Jan 1 2012

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Uterine Cervical Neoplasms
India
Carcinoma
Polymerase Chain Reaction
Infection
Uterine Cervical Dysplasia
Human papillomavirus 16
DNA
Case-Control Studies
Vaccination
Pregnancy

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Vinodhini, Krishnakumar ; Santhanam, Shanmughapriya ; Sanmugham, Sumathy ; Senthikumar, Ganesan ; Das, Bhudev C. ; Natarajaseenivasan, Kalimuthusamy. / Prevalence of high-risk HPV and associated risk factors in cases of cervical carcinoma in Tamil Nadu, India. In: International Journal of Gynecology and Obstetrics. 2012 ; Vol. 119, No. 3. pp. 253-256.
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Prevalence of high-risk HPV and associated risk factors in cases of cervical carcinoma in Tamil Nadu, India. / Vinodhini, Krishnakumar; Santhanam, Shanmughapriya; Sanmugham, Sumathy; Senthikumar, Ganesan; Das, Bhudev C.; Natarajaseenivasan, Kalimuthusamy.

In: International Journal of Gynecology and Obstetrics, Vol. 119, No. 3, 01.01.2012, p. 253-256.

Research output: Contribution to journalArticle

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N2 - Objective: To assess the prevalence of HPV infection among women with cervical cancer in Tiruchirapalli, Tamil Nadu, India. Methods: A case-control study was conducted with 246 women with cervical cancer and 257 control participants aged between 20 and 70 years. The presence of HPV DNA was determined using the MY09/11 PCR protocol, the GP5+/6+ PCR protocol, and type-specific PCR-based assays. Results: The overall HPV prevalence was 54.9% and HPV 16 was the most prevalent type. The women the most vulnerable for HPV infection were those aged 41 to 60 years. The major contributing risk factors for cervical cancer were having had 3 or more pregnancies (OR 19.2; 95% CI, 10.78-10.16); harboring high-risk HPV DNA (OR 15.3; 95% CI, 9.81-23.8); being a manual worker (OR 14.9; 95% CI, 9.62-23.08); being illiterate (OR 8.28; 95% CI, 5.51-12.43); and having never been screened for cervical dysplasia (OR 6.70; 95% CI, 10.78-34.44). Conclusion: The present report on the overall and type-specific prevalence rates and risk burden of HPV infection in Tamil Nadu confirms that screening and vaccination programs are urgently needed in this state to overcome the burden of HPV-associated cervical cancer.

AB - Objective: To assess the prevalence of HPV infection among women with cervical cancer in Tiruchirapalli, Tamil Nadu, India. Methods: A case-control study was conducted with 246 women with cervical cancer and 257 control participants aged between 20 and 70 years. The presence of HPV DNA was determined using the MY09/11 PCR protocol, the GP5+/6+ PCR protocol, and type-specific PCR-based assays. Results: The overall HPV prevalence was 54.9% and HPV 16 was the most prevalent type. The women the most vulnerable for HPV infection were those aged 41 to 60 years. The major contributing risk factors for cervical cancer were having had 3 or more pregnancies (OR 19.2; 95% CI, 10.78-10.16); harboring high-risk HPV DNA (OR 15.3; 95% CI, 9.81-23.8); being a manual worker (OR 14.9; 95% CI, 9.62-23.08); being illiterate (OR 8.28; 95% CI, 5.51-12.43); and having never been screened for cervical dysplasia (OR 6.70; 95% CI, 10.78-34.44). Conclusion: The present report on the overall and type-specific prevalence rates and risk burden of HPV infection in Tamil Nadu confirms that screening and vaccination programs are urgently needed in this state to overcome the burden of HPV-associated cervical cancer.

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