Prevalence of hypermobile Ehlers-Danlos syndrome in postural orthostatic tachycardia syndrome

Amanda J. Miller; Lauren E. Stiles; Timothy Sheehan; Rebecca Bascom; Howard P. Levy; Clair A. Francomano; Amy C. Arnold

doi:10.1016/j.autneu.2020.102637

Prevalence of hypermobile Ehlers-Danlos syndrome in postural orthostatic tachycardia syndrome

Amanda J. Miller, Lauren E. Stiles, Timothy Sheehan, Rebecca Bascom, Howard P. Levy, Clair A. Francomano, Amy C. Arnold

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Despite well-established clinical associations between Hypermobile Ehlers-Danlos syndrome (hEDS) and postural orthostatic tachycardia syndrome (POTS), the precise prevalence is unknown. We therefore evaluated for hEDS in 91 POTS participants using the 2017 hEDS diagnostic checklist, which has three major criteria: 1) generalized joint hypermobility (Beighton score), 2) systemic features, family history, and 3) absence of exclusion criteria. Overall, 28 out of 91 POTS participants (31%) met clinical criteria for hEDS. An additional 24% of participants had generalized joint hypermobility without meeting hEDS criteria. Identifying the prevalence of hEDS in POTS is important for understanding possible mechanisms connecting these two syndromes.

Original language	English (US)
Article number	102637
Journal	Autonomic Neuroscience: Basic and Clinical
Volume	224
DOIs	https://doi.org/10.1016/j.autneu.2020.102637
State	Published - Mar 2020

All Science Journal Classification (ASJC) codes

Endocrine and Autonomic Systems
Clinical Neurology
Cellular and Molecular Neuroscience

Access to Document

10.1016/j.autneu.2020.102637

Fingerprint Dive into the research topics of 'Prevalence of hypermobile Ehlers-Danlos syndrome in postural orthostatic tachycardia syndrome'. Together they form a unique fingerprint.

Cite this

@article{66bbcfe01abd446aad65f7a37ed17e1b,

title = "Prevalence of hypermobile Ehlers-Danlos syndrome in postural orthostatic tachycardia syndrome",

abstract = "Despite well-established clinical associations between Hypermobile Ehlers-Danlos syndrome (hEDS) and postural orthostatic tachycardia syndrome (POTS), the precise prevalence is unknown. We therefore evaluated for hEDS in 91 POTS participants using the 2017 hEDS diagnostic checklist, which has three major criteria: 1) generalized joint hypermobility (Beighton score), 2) systemic features, family history, and 3) absence of exclusion criteria. Overall, 28 out of 91 POTS participants (31%) met clinical criteria for hEDS. An additional 24% of participants had generalized joint hypermobility without meeting hEDS criteria. Identifying the prevalence of hEDS in POTS is important for understanding possible mechanisms connecting these two syndromes.",

author = "Miller, {Amanda J.} and Stiles, {Lauren E.} and Timothy Sheehan and Rebecca Bascom and Levy, {Howard P.} and Francomano, {Clair A.} and Arnold, {Amy C.}",

year = "2020",

month = mar,

doi = "10.1016/j.autneu.2020.102637",

language = "English (US)",

volume = "224",

journal = "Autonomic Neuroscience: Basic and Clinical",

issn = "1566-0702",

publisher = "Elsevier",

}

TY - JOUR

T1 - Prevalence of hypermobile Ehlers-Danlos syndrome in postural orthostatic tachycardia syndrome

AU - Miller, Amanda J.

AU - Stiles, Lauren E.

AU - Sheehan, Timothy

AU - Bascom, Rebecca

AU - Levy, Howard P.

AU - Francomano, Clair A.

AU - Arnold, Amy C.

PY - 2020/3

Y1 - 2020/3

N2 - Despite well-established clinical associations between Hypermobile Ehlers-Danlos syndrome (hEDS) and postural orthostatic tachycardia syndrome (POTS), the precise prevalence is unknown. We therefore evaluated for hEDS in 91 POTS participants using the 2017 hEDS diagnostic checklist, which has three major criteria: 1) generalized joint hypermobility (Beighton score), 2) systemic features, family history, and 3) absence of exclusion criteria. Overall, 28 out of 91 POTS participants (31%) met clinical criteria for hEDS. An additional 24% of participants had generalized joint hypermobility without meeting hEDS criteria. Identifying the prevalence of hEDS in POTS is important for understanding possible mechanisms connecting these two syndromes.

AB - Despite well-established clinical associations between Hypermobile Ehlers-Danlos syndrome (hEDS) and postural orthostatic tachycardia syndrome (POTS), the precise prevalence is unknown. We therefore evaluated for hEDS in 91 POTS participants using the 2017 hEDS diagnostic checklist, which has three major criteria: 1) generalized joint hypermobility (Beighton score), 2) systemic features, family history, and 3) absence of exclusion criteria. Overall, 28 out of 91 POTS participants (31%) met clinical criteria for hEDS. An additional 24% of participants had generalized joint hypermobility without meeting hEDS criteria. Identifying the prevalence of hEDS in POTS is important for understanding possible mechanisms connecting these two syndromes.

UR - http://www.scopus.com/inward/record.url?scp=85077915102&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85077915102&partnerID=8YFLogxK

U2 - 10.1016/j.autneu.2020.102637

DO - 10.1016/j.autneu.2020.102637

M3 - Article

C2 - 31954224

AN - SCOPUS:85077915102

VL - 224

JO - Autonomic Neuroscience: Basic and Clinical

JF - Autonomic Neuroscience: Basic and Clinical

SN - 1566-0702

M1 - 102637

ER -