TY - JOUR
T1 - Prevalence of hypermobile Ehlers-Danlos syndrome in postural orthostatic tachycardia syndrome
AU - Miller, Amanda J.
AU - Stiles, Lauren E.
AU - Sheehan, Timothy
AU - Bascom, Rebecca
AU - Levy, Howard P.
AU - Francomano, Clair A.
AU - Arnold, Amy C.
N1 - Funding Information:
This work was funded by Dysautonomia International. The authors are supported by NIH R00HL122507 (to A.C.A.) and by American Heart Association 18POST33960087 (to A.J.M). We want to acknowledge the volunteers from Dysautonomia International who assisted with this study including Aly Aylward, Zachary Orban, and Kate Bourne.
Funding Information:
This work was funded by Dysautonomia International. The authors are supported by NIH R00HL122507 (to A.C.A.) and by American Heart Association 18POST33960087 (to A.J.M). We want to acknowledge the volunteers from Dysautonomia International who assisted with this study including Aly Aylward, Zachary Orban, and Kate Bourne. On behalf of all authors, the corresponding author states that there is no conflict of interest.
Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/3
Y1 - 2020/3
N2 - Despite well-established clinical associations between Hypermobile Ehlers-Danlos syndrome (hEDS) and postural orthostatic tachycardia syndrome (POTS), the precise prevalence is unknown. We therefore evaluated for hEDS in 91 POTS participants using the 2017 hEDS diagnostic checklist, which has three major criteria: 1) generalized joint hypermobility (Beighton score), 2) systemic features, family history, and 3) absence of exclusion criteria. Overall, 28 out of 91 POTS participants (31%) met clinical criteria for hEDS. An additional 24% of participants had generalized joint hypermobility without meeting hEDS criteria. Identifying the prevalence of hEDS in POTS is important for understanding possible mechanisms connecting these two syndromes.
AB - Despite well-established clinical associations between Hypermobile Ehlers-Danlos syndrome (hEDS) and postural orthostatic tachycardia syndrome (POTS), the precise prevalence is unknown. We therefore evaluated for hEDS in 91 POTS participants using the 2017 hEDS diagnostic checklist, which has three major criteria: 1) generalized joint hypermobility (Beighton score), 2) systemic features, family history, and 3) absence of exclusion criteria. Overall, 28 out of 91 POTS participants (31%) met clinical criteria for hEDS. An additional 24% of participants had generalized joint hypermobility without meeting hEDS criteria. Identifying the prevalence of hEDS in POTS is important for understanding possible mechanisms connecting these two syndromes.
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U2 - 10.1016/j.autneu.2020.102637
DO - 10.1016/j.autneu.2020.102637
M3 - Article
C2 - 31954224
AN - SCOPUS:85077915102
VL - 224
JO - Journal of the Autonomic Nervous System
JF - Journal of the Autonomic Nervous System
SN - 1566-0702
M1 - 102637
ER -