Prevention and treatment of central nervous system involvement by non-Hodgkin's lymphoma: A review of the literature

Natalia Colocci, Michael Glantz, Lawrence Recht

Research output: Contribution to journalReview article

28 Citations (Scopus)

Abstract

Direct invasion of the central nervous system (CNS) occurs in 5% of all patients with non-Hodgkin's lymphoma, either at the time of presentation, as a solitary site of relapse, or during the course of progressive disease. Over the last several years, several studies, mostly retrospective, have analyzed risk factors associated with this complication as well as various methods to both treat and prevent it. A systematic review of the literature reveals that although a profile of a patient at particularly high risk for developing disease can be identified, treatments are for the most part ineffective at improving survival in patients with CNS lymphoma, and there is no high-quality evidence that prophylaxis prevents its occurrence. A randomized controlled trial to assess the value of prophylaxis in this disease is warranted, and suggestions for how such a trial might be designed are included in this review.

Original languageEnglish (US)
Pages (from-to)395-404
Number of pages10
JournalSeminars in Neurology
Volume24
Issue number4
DOIs
StatePublished - Dec 1 2004

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Non-Hodgkin's Lymphoma
Central Nervous System
Lymphoma
Therapeutics
Randomized Controlled Trials
Retrospective Studies
Recurrence
Survival

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Neuroscience(all)

Cite this

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abstract = "Direct invasion of the central nervous system (CNS) occurs in 5{\%} of all patients with non-Hodgkin's lymphoma, either at the time of presentation, as a solitary site of relapse, or during the course of progressive disease. Over the last several years, several studies, mostly retrospective, have analyzed risk factors associated with this complication as well as various methods to both treat and prevent it. A systematic review of the literature reveals that although a profile of a patient at particularly high risk for developing disease can be identified, treatments are for the most part ineffective at improving survival in patients with CNS lymphoma, and there is no high-quality evidence that prophylaxis prevents its occurrence. A randomized controlled trial to assess the value of prophylaxis in this disease is warranted, and suggestions for how such a trial might be designed are included in this review.",
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Prevention and treatment of central nervous system involvement by non-Hodgkin's lymphoma : A review of the literature. / Colocci, Natalia; Glantz, Michael; Recht, Lawrence.

In: Seminars in Neurology, Vol. 24, No. 4, 01.12.2004, p. 395-404.

Research output: Contribution to journalReview article

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AU - Glantz, Michael

AU - Recht, Lawrence

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