Prevention and treatment options for postoperative Crohn's disease

A clinical dilemma

Kofi Clarke, Miguel Regueiro

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The majority of patients with Crohn's disease require surgery for disease-related complications. Postoperative Crohn's disease recurrence is common after intestinal resection. The optimal management strategy for postoperative recurrence of Crohn's disease is controversial. In the absence of universally adopted guidelines, clinicians and patients must discuss and weigh the risks and benefits of postoperative pharmacotherapy. Those patients at low risk of disease recurrence may not require treatment. On the other hand, patients with more aggressive disease and high risk of recurrence may be best treated early in the postoperative period with an immunomodulator or antitumor necrosis factor agents. Ideally, postoperative treatment decisions would be made using predictable, reliable, and reproducible clinical prediction criteria that would guide treatment. This article reviews the data on postoperative Crohn's disease, including predictors of early recurrence, available options for postoperative monitoring, timing of initiation, and choice of postoperative therapy for prevention and management.

Original languageEnglish (US)
Pages (from-to)581-588
Number of pages8
JournalGastroenterology and Hepatology
Volume5
Issue number8
StatePublished - Aug 1 2009

Fingerprint

Crohn Disease
Recurrence
Therapeutics
Immunologic Factors
Postoperative Period
Necrosis
Guidelines
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

@article{e5f59413a7474a99a6c99845f833422e,
title = "Prevention and treatment options for postoperative Crohn's disease: A clinical dilemma",
abstract = "The majority of patients with Crohn's disease require surgery for disease-related complications. Postoperative Crohn's disease recurrence is common after intestinal resection. The optimal management strategy for postoperative recurrence of Crohn's disease is controversial. In the absence of universally adopted guidelines, clinicians and patients must discuss and weigh the risks and benefits of postoperative pharmacotherapy. Those patients at low risk of disease recurrence may not require treatment. On the other hand, patients with more aggressive disease and high risk of recurrence may be best treated early in the postoperative period with an immunomodulator or antitumor necrosis factor agents. Ideally, postoperative treatment decisions would be made using predictable, reliable, and reproducible clinical prediction criteria that would guide treatment. This article reviews the data on postoperative Crohn's disease, including predictors of early recurrence, available options for postoperative monitoring, timing of initiation, and choice of postoperative therapy for prevention and management.",
author = "Kofi Clarke and Miguel Regueiro",
year = "2009",
month = "8",
day = "1",
language = "English (US)",
volume = "5",
pages = "581--588",
journal = "Gastroenterology and Hepatology",
issn = "1554-7914",
publisher = "Gastro-Hep Communications, Inc.",
number = "8",

}

Prevention and treatment options for postoperative Crohn's disease : A clinical dilemma. / Clarke, Kofi; Regueiro, Miguel.

In: Gastroenterology and Hepatology, Vol. 5, No. 8, 01.08.2009, p. 581-588.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Prevention and treatment options for postoperative Crohn's disease

T2 - A clinical dilemma

AU - Clarke, Kofi

AU - Regueiro, Miguel

PY - 2009/8/1

Y1 - 2009/8/1

N2 - The majority of patients with Crohn's disease require surgery for disease-related complications. Postoperative Crohn's disease recurrence is common after intestinal resection. The optimal management strategy for postoperative recurrence of Crohn's disease is controversial. In the absence of universally adopted guidelines, clinicians and patients must discuss and weigh the risks and benefits of postoperative pharmacotherapy. Those patients at low risk of disease recurrence may not require treatment. On the other hand, patients with more aggressive disease and high risk of recurrence may be best treated early in the postoperative period with an immunomodulator or antitumor necrosis factor agents. Ideally, postoperative treatment decisions would be made using predictable, reliable, and reproducible clinical prediction criteria that would guide treatment. This article reviews the data on postoperative Crohn's disease, including predictors of early recurrence, available options for postoperative monitoring, timing of initiation, and choice of postoperative therapy for prevention and management.

AB - The majority of patients with Crohn's disease require surgery for disease-related complications. Postoperative Crohn's disease recurrence is common after intestinal resection. The optimal management strategy for postoperative recurrence of Crohn's disease is controversial. In the absence of universally adopted guidelines, clinicians and patients must discuss and weigh the risks and benefits of postoperative pharmacotherapy. Those patients at low risk of disease recurrence may not require treatment. On the other hand, patients with more aggressive disease and high risk of recurrence may be best treated early in the postoperative period with an immunomodulator or antitumor necrosis factor agents. Ideally, postoperative treatment decisions would be made using predictable, reliable, and reproducible clinical prediction criteria that would guide treatment. This article reviews the data on postoperative Crohn's disease, including predictors of early recurrence, available options for postoperative monitoring, timing of initiation, and choice of postoperative therapy for prevention and management.

UR - http://www.scopus.com/inward/record.url?scp=70350155743&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350155743&partnerID=8YFLogxK

M3 - Review article

VL - 5

SP - 581

EP - 588

JO - Gastroenterology and Hepatology

JF - Gastroenterology and Hepatology

SN - 1554-7914

IS - 8

ER -