Prevention of the TPA-mediated down-regulation of protein kinase C

Deborah S. Grove; Andrea M. Mastro

doi:10.1016/0006-291X(88)90563-3

Prevention of the TPA-mediated down-regulation of protein kinase C

Deborah S. Grove, Andrea M. Mastro

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Protein kinase C activity in lymphocytes was down-regulated upon exposure of the cells to 12-0-tetradecanoylphorbol-13 acetate. This down-regulation was prevented by preincubating the cells with sphingosine, a reported protein kinase C inhibitor. Two other protein kinase C inhibitors, palmitoylcarnitine and phloretin, were ineffective in preventing down-regulation by the phorbol ester.

Original language	English (US)
Pages (from-to)	94-99
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	151
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(88)90563-3
State	Published - Feb 29 1988

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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abstract = "Protein kinase C activity in lymphocytes was down-regulated upon exposure of the cells to 12-0-tetradecanoylphorbol-13 acetate. This down-regulation was prevented by preincubating the cells with sphingosine, a reported protein kinase C inhibitor. Two other protein kinase C inhibitors, palmitoylcarnitine and phloretin, were ineffective in preventing down-regulation by the phorbol ester.",

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AU - Mastro, Andrea M.

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AB - Protein kinase C activity in lymphocytes was down-regulated upon exposure of the cells to 12-0-tetradecanoylphorbol-13 acetate. This down-regulation was prevented by preincubating the cells with sphingosine, a reported protein kinase C inhibitor. Two other protein kinase C inhibitors, palmitoylcarnitine and phloretin, were ineffective in preventing down-regulation by the phorbol ester.

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Prevention of the TPA-mediated down-regulation of protein kinase C

Abstract

All Science Journal Classification (ASJC) codes

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