Prevention of the TPA-mediated down-regulation of protein kinase C

Deborah S. Grove, Andrea M. Mastro

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Protein kinase C activity in lymphocytes was down-regulated upon exposure of the cells to 12-0-tetradecanoylphorbol-13 acetate. This down-regulation was prevented by preincubating the cells with sphingosine, a reported protein kinase C inhibitor. Two other protein kinase C inhibitors, palmitoylcarnitine and phloretin, were ineffective in preventing down-regulation by the phorbol ester.

Original languageEnglish (US)
Pages (from-to)94-99
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume151
Issue number1
DOIs
StatePublished - Feb 29 1988

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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