Primary chondrosarcomas of the larynx treated with proton radiotherapy: A single institutional experience

Sean S. Mahase, Bhuvanesh Singh, Richard J. Wong, Ian Ganly, Jay O. Boyle, Snehal G. Patel, Nancy Y. Lee

Research output: Contribution to journalArticlepeer-review


Background: Primary laryngeal chondrosarcomas are rare entities whose excellent survival rates following resection promote conservative surgical approaches to maintain quality of life without compromising outcomes. There are excellent outcomes in skull base chondrosarcomas treated with maximal safe resection and post-operative proton therapy. Extrapolating from these findings, we report our institutional experience treating symptomatic or growing laryngeal chondrosarcomas using proton beam therapy. Cases: Demographic information, clinical characteristics, treatment details, and follow-up data were collected and summarized. Patients were monitored with serial imaging and examination. Stable disease was defined as no progression of disease on imaging. Two patients underwent subtotal resections followed by post-operative radiotherapy, while two patients received definitive radiotherapy. All patients are currently alive with stable disease at their last follow-up. Conclusion: This case series provides initial evidence for excellent outcomes with maximal safe surgical resection followed by proton beam therapy for patients with symptomatic or growing laryngeal chondrosarcomas. Larger studies are warranted to determine the optimal therapeutic approach.

Original languageEnglish (US)
Article numbere1621
JournalCancer Reports
Issue number9
StatePublished - Sep 2022

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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