Primary cilia mediate PGE2 release in MC3T3-E1 osteoblasts

A. M.D. Malone, Charles T. Anderson, P. Tummala, T. Stearns, C. R. Jacobs

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

To determine whether primary cilia act as mechanosensors in bone, intracellular calcium release and prostaglandin E2 release were examined. The existence of primary cilia in bone tissue was confirmed using immunoflourescent detection of acetylated α-tubulin. PGE2 was quantifued using a commercial ELISA kiet and normalized to total protein. Real-time intracellular levels of calcium were quantified.

Original languageEnglish (US)
Pages (from-to)207-208
Number of pages2
JournalMCB Molecular and Cellular Biomechanics
Volume3
Issue number4
StatePublished - Dec 1 2006

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Molecular Medicine
  • Molecular Biology
  • Cell Biology

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    Malone, A. M. D., Anderson, C. T., Tummala, P., Stearns, T., & Jacobs, C. R. (2006). Primary cilia mediate PGE2 release in MC3T3-E1 osteoblasts. MCB Molecular and Cellular Biomechanics, 3(4), 207-208.