Primary Intestinal and Vertebral Chordomas in Laboratory Zebrafish (Danio rerio)

Timothy Cooper, K. N. Murray, S. Spagnoli, J. M. Spitsbergen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Chordomas are uncommon neoplasms arising from notochord remnants, most commonly occurring in the axial skeleton. Extraskeletal soft tissue chordomas are rare primary tumors, and primary alimentary tract chordomas have not been reported. Herein we report 24 cases of spontaneous primary intestinal chordomas in zebrafish, as well as 9 spontaneous vertebral chordomas. Both intestinal and vertebral tumors showed invasive behavior, although more commonly in the latter. In all cases of primary intestinal chordomas, there was no axial or peripheral skeletal or other nonvisceral involvement. Although uncommon, intestinal chordomas represent a unique background lesion in aged zebrafish.

Original languageEnglish (US)
Pages (from-to)388-392
Number of pages5
JournalVeterinary Pathology
Volume52
Issue number2
DOIs
StatePublished - Mar 16 2015

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Chordoma
Zebrafish
Danio rerio
neoplasms
lesions (animal)
skeleton
Notochord
Neoplasms
Skeleton

All Science Journal Classification (ASJC) codes

  • veterinary(all)

Cite this

Cooper, Timothy ; Murray, K. N. ; Spagnoli, S. ; Spitsbergen, J. M. / Primary Intestinal and Vertebral Chordomas in Laboratory Zebrafish (Danio rerio). In: Veterinary Pathology. 2015 ; Vol. 52, No. 2. pp. 388-392.
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Cooper, T, Murray, KN, Spagnoli, S & Spitsbergen, JM 2015, 'Primary Intestinal and Vertebral Chordomas in Laboratory Zebrafish (Danio rerio)', Veterinary Pathology, vol. 52, no. 2, pp. 388-392. https://doi.org/10.1177/0300985814537531

Primary Intestinal and Vertebral Chordomas in Laboratory Zebrafish (Danio rerio). / Cooper, Timothy; Murray, K. N.; Spagnoli, S.; Spitsbergen, J. M.

In: Veterinary Pathology, Vol. 52, No. 2, 16.03.2015, p. 388-392.

Research output: Contribution to journalArticle

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