TY - JOUR
T1 - Primary intracranial germ cell tumors
T2 - Clinicopathologic review of 32 cases
AU - Salzman, K. L.
AU - Rojiani, A. M.
AU - Buatti, J.
AU - Quisling, R. G.
AU - Marcus, R. B.
AU - Maria, B. L.
AU - Mickle, J. P.
AU - Kedar, A.
PY - 1997
Y1 - 1997
N2 - Primary intracranial germ cell neoplasms are rare tumors and constitute a heterogenous group. We have reviewed 32 cases, over a 21-year period, from the University of Florida. The cases include 22 germinomas, 6 mixed germ cell tumors, and 4 teratomas. The clinical presentations in these cases were more closely related to the location of the tumor, that is, pineal or suprasellar, rather than the histologic subtype. Neuroimaging evaluations was useful in distinguishing between germinomas, teratomas, and other mixed germ cell tumors (MGCTs), primarily by evaluation of cystic versus solid lesions (teratoma versus germinoma), contents of cysts (teratoma versus MGCT), and infiltrative nature of the tumors (MGCT), although cytologic-histopathologic confirmation remains necessary. Germinomas responded favorably to radiation therapy with survival periods of over 16 years; MGCTs were treated with combination chemotherapy and radiation, with a markedly poorer prognosis. This study underlines the critical significance of histopathologic evaluation of the tumor in determining therapeutic interventions as well as prognosis.
AB - Primary intracranial germ cell neoplasms are rare tumors and constitute a heterogenous group. We have reviewed 32 cases, over a 21-year period, from the University of Florida. The cases include 22 germinomas, 6 mixed germ cell tumors, and 4 teratomas. The clinical presentations in these cases were more closely related to the location of the tumor, that is, pineal or suprasellar, rather than the histologic subtype. Neuroimaging evaluations was useful in distinguishing between germinomas, teratomas, and other mixed germ cell tumors (MGCTs), primarily by evaluation of cystic versus solid lesions (teratoma versus germinoma), contents of cysts (teratoma versus MGCT), and infiltrative nature of the tumors (MGCT), although cytologic-histopathologic confirmation remains necessary. Germinomas responded favorably to radiation therapy with survival periods of over 16 years; MGCTs were treated with combination chemotherapy and radiation, with a markedly poorer prognosis. This study underlines the critical significance of histopathologic evaluation of the tumor in determining therapeutic interventions as well as prognosis.
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U2 - 10.1080/15513819709168597
DO - 10.1080/15513819709168597
M3 - Review article
C2 - 9267886
AN - SCOPUS:0030742214
VL - 17
SP - 713
EP - 727
JO - Pediatric Pathology and Molecular Medicine
JF - Pediatric Pathology and Molecular Medicine
SN - 1551-3815
IS - 5
ER -