Primary pulmonary hypertension in patients with classic hemophilia

G. H. Goldsmith, R. G. Baily, D. B. Brettler, W. R. Davidson, James Ballard, T. E. Driscol, M. Joshua, J. M. Greenberg, C. K. Kasper, P. H. Levine, O. D. Ratnoff

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Abstract

Five patients with classic hemophilia were found to have primary pulmonary hypertension, a disorder not previously recognized in this population. All patients had had their coagulation disorder treated for 10 years or more with self-administered lyophilized concentrates of factor VIII, and all had antibodies to human immunodeficiency virus (HIV). Primary pulmonary hypertension was confirmed by histologic means at autopsy in one patient and by lung biopsy findings in another. In the other three patients, the findings are in agreement with this diagnosis. No patient had underlying cardiac or pulmonary disease, or clinical or pathologic evidence of collagen-vascular disease, exposure to anorexigenic agents. Whether the primary pulmonary hypertension was related to treatment with lyophilized factor VIII, or to presence of antibodies to HIV, or both, is unknown.

Original languageEnglish (US)
Pages (from-to)797-799
Number of pages3
JournalAnnals of Internal Medicine
Volume108
Issue number6
DOIs
StatePublished - Jan 1 1988

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Hemophilia A
Factor VIII
HIV
Collagen Diseases
Antibodies
Vascular Diseases
Lung Diseases
Autopsy
Heart Diseases
Familial Primary Pulmonary Hypertension
Biopsy
Lung
Population

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Goldsmith, G. H., Baily, R. G., Brettler, D. B., Davidson, W. R., Ballard, J., Driscol, T. E., ... Ratnoff, O. D. (1988). Primary pulmonary hypertension in patients with classic hemophilia. Annals of Internal Medicine, 108(6), 797-799. https://doi.org/10.7326/0003-4819-108-6-797
Goldsmith, G. H. ; Baily, R. G. ; Brettler, D. B. ; Davidson, W. R. ; Ballard, James ; Driscol, T. E. ; Joshua, M. ; Greenberg, J. M. ; Kasper, C. K. ; Levine, P. H. ; Ratnoff, O. D. / Primary pulmonary hypertension in patients with classic hemophilia. In: Annals of Internal Medicine. 1988 ; Vol. 108, No. 6. pp. 797-799.
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Goldsmith, GH, Baily, RG, Brettler, DB, Davidson, WR, Ballard, J, Driscol, TE, Joshua, M, Greenberg, JM, Kasper, CK, Levine, PH & Ratnoff, OD 1988, 'Primary pulmonary hypertension in patients with classic hemophilia', Annals of Internal Medicine, vol. 108, no. 6, pp. 797-799. https://doi.org/10.7326/0003-4819-108-6-797

Primary pulmonary hypertension in patients with classic hemophilia. / Goldsmith, G. H.; Baily, R. G.; Brettler, D. B.; Davidson, W. R.; Ballard, James; Driscol, T. E.; Joshua, M.; Greenberg, J. M.; Kasper, C. K.; Levine, P. H.; Ratnoff, O. D.

In: Annals of Internal Medicine, Vol. 108, No. 6, 01.01.1988, p. 797-799.

Research output: Contribution to journalArticle

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Goldsmith GH, Baily RG, Brettler DB, Davidson WR, Ballard J, Driscol TE et al. Primary pulmonary hypertension in patients with classic hemophilia. Annals of Internal Medicine. 1988 Jan 1;108(6):797-799. https://doi.org/10.7326/0003-4819-108-6-797