Probiotics for Clostridium difficile diarrhea

Putting it into perspective

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Clostridium difficile diarrhea is an expensive, life-threatening infection associated with serious morbidity and mortality, even among previously healthy individuals. Relapses from the infection are common following standard antibiotic treatments, with 3-5% of patients who contract C. difficile diarrhea unable to discontinue vancomycin due to continual relapses. Such patients may have a focal immunodeficiency in which they fail to mount an immune response against C. difficile. For these individuals, antimicrobial therapies are unable to eradicate the microorganism because no antibiotics are capable of killing C. difficile spores. Although they are considered alternative medicine, probiotics have provided a safe and effective means of restoring gastrointestinal flora and alleviating diarrhea, particularly for individuals experiencing multiple relapses.

Original languageEnglish (US)
Pages (from-to)1284-1287
Number of pages4
JournalAnnals of Pharmacotherapy
Volume41
Issue number7-8
DOIs
StatePublished - Jul 1 2007

Fingerprint

Clostridium difficile
Probiotics
Diarrhea
Recurrence
Anti-Bacterial Agents
Vancomycin
Complementary Therapies
Contracts
Infection
Spores
Morbidity
Mortality
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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title = "Probiotics for Clostridium difficile diarrhea: Putting it into perspective",
abstract = "Clostridium difficile diarrhea is an expensive, life-threatening infection associated with serious morbidity and mortality, even among previously healthy individuals. Relapses from the infection are common following standard antibiotic treatments, with 3-5{\%} of patients who contract C. difficile diarrhea unable to discontinue vancomycin due to continual relapses. Such patients may have a focal immunodeficiency in which they fail to mount an immune response against C. difficile. For these individuals, antimicrobial therapies are unable to eradicate the microorganism because no antibiotics are capable of killing C. difficile spores. Although they are considered alternative medicine, probiotics have provided a safe and effective means of restoring gastrointestinal flora and alleviating diarrhea, particularly for individuals experiencing multiple relapses.",
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Probiotics for Clostridium difficile diarrhea : Putting it into perspective. / Karpa, Kelly Dowhower.

In: Annals of Pharmacotherapy, Vol. 41, No. 7-8, 01.07.2007, p. 1284-1287.

Research output: Contribution to journalReview article

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AB - Clostridium difficile diarrhea is an expensive, life-threatening infection associated with serious morbidity and mortality, even among previously healthy individuals. Relapses from the infection are common following standard antibiotic treatments, with 3-5% of patients who contract C. difficile diarrhea unable to discontinue vancomycin due to continual relapses. Such patients may have a focal immunodeficiency in which they fail to mount an immune response against C. difficile. For these individuals, antimicrobial therapies are unable to eradicate the microorganism because no antibiotics are capable of killing C. difficile spores. Although they are considered alternative medicine, probiotics have provided a safe and effective means of restoring gastrointestinal flora and alleviating diarrhea, particularly for individuals experiencing multiple relapses.

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