Proceedings from the Second Haploidentical Stem Cell Transplantation Symposium-Haplo2014, San Francisco, California, December 4, 2014

Monzr M. Al Malki, Mary Horowitz, Rupert Handgretinger, Wing Leung, Denis Claude Roy, Xiao Jun Huang, Ephraim Fuchs, Franco Locatelli, Didier Blaise, Shin Mineishi, Massimo Martelli, Jeffrey Miller, Carl June, Hui sheng Ai, Leo Luznik, Domenico Mavilio, Enrico Lugli, Marcel R.M. van den Brink, Richard E. Champlin, Stefan O. Ciurea

Research output: Contribution to journalArticle

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Abstract

Significant progress has been made over the past decade in haploidentical transplantation, with the development of novel methods to control intense alloreactive reactions generated in the major HLA-mismatched setting. Application of post-transplantation cyclophosphamide has gained worldwide acceptance as an effective and low-cost way to perform this type of transplantation, with outcomes now similar to those from HLA-matched unrelated donors. These advances have resulted in improved treatment-related mortality, whereas disease relapse has emerged as the most common cause of treatment failure. In addition, improvements in immunologic reconstitution after transplantation are much needed, not only in haploidentical transplantation but in all forms of stem cell transplantation. This symposium has focused on some of the most promising methods to control alloreactivity in this form of transplantation and application of cellular therapy to prevent disease relapse after transplantation, as well as understanding immunologic reconstitution and foreseeable approaches to improve immune recovery after transplantation.

Original languageEnglish (US)
Pages (from-to)594-604
Number of pages11
JournalBiology of Blood and Marrow Transplantation
Volume22
Issue number4
DOIs
StatePublished - Apr 1 2016

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

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    Al Malki, M. M., Horowitz, M., Handgretinger, R., Leung, W., Roy, D. C., Huang, X. J., Fuchs, E., Locatelli, F., Blaise, D., Mineishi, S., Martelli, M., Miller, J., June, C., Ai, H. S., Luznik, L., Mavilio, D., Lugli, E., van den Brink, M. R. M., Champlin, R. E., & Ciurea, S. O. (2016). Proceedings from the Second Haploidentical Stem Cell Transplantation Symposium-Haplo2014, San Francisco, California, December 4, 2014. Biology of Blood and Marrow Transplantation, 22(4), 594-604. https://doi.org/10.1016/j.bbmt.2016.01.001