Production of solavetivone by immobilized cells of Hyoscyamus muticus

S. V. Ramakrishna, G. Ramakrishna Reddy, Wayne R. Curtis, Arthur E. Humphrey

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The secretion of solavetivone, a phytoalexin, by the cells of Hyoscyamus muticus in response to fungal elicitation has been enhanced by gel entrapment in calcium alginate. The immobilized cells produced 53% higher product and exhibited sustained biosynthetic activity in repeated batch cycles when compared with suspended cells. Providing a non-elicited media exchange and a sufficient interval of time between repeated infection (elicitation) gave greater productivity. Apparently the cells need a period to recover from the infection.

Original languageEnglish (US)
Pages (from-to)301-306
Number of pages6
JournalBiotechnology Letters
Volume15
Issue number3
DOIs
Publication statusPublished - Mar 1 1993

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All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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