The need for yield estimation strategies in the design stage is a priority recognized by industry. Yield estimates can be employed to assess the manufacturability of a design, and allow for modification to produce a robust design. Therefore, low yield of products can be avoided and costs for manufacturing can be reduced. This paper presents an accurate and timeefficient yield estimation approach for use with simulation models. We use a metamodel-based method, which is timeefficient compared to crude Monte Carlo yield estimation using the original simulation code. The approach employs a boundary-focused experiment design, which overcomes the inaccuracy of yield estimates that can occur when using a metamodel method. The results of two examples demonstrate the effectiveness of this new approach.