Prognostic factors and predictive tools for upper tract urothelial carcinoma

a systematic review

Aurélie Mbeutcha, Morgan Rouprêt, Ashish M. Kamat, Pierre I. Karakiewicz, Nathan Lawrentschuk, Giacomo Novara, Jay Raman, Christian Seitz, Evanguelos Xylinas, Shahrokh F. Shariat

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Background: Upper tract urothelial carcinoma (UTUC) is a rare and heterogeneous disease. Several clinical and biological prognostic factors have been identified in multi-institutional collaborative works with the aim of helping decision-making in pursuit of tailored individual patient care. This review provides an overview of these existing prognostic factors and predictive tools for the management of patients with UTUC. Methods: A systematic literature search was performed using PubMed/MEDLINE, Web of Science and Scopus databases regarding articles published in English between January 2000 and November 2015 according to PRISMA guidelines. Thresholds of 100 and 300 patients were applied for studies on biomarkers and clinical studies, respectively. All the studies on predictive tools were included for analysis. Outcomes of interest were features associated with advanced-stage UTUC, disease recurrence and survival. Results: A total of 116 studies were included in this review. These large and/or multi-institutional studies have confirmed the prognostic value of standard pathological factors (i.e., tumor stage, grade and lymph node metastasis) and identified novel features such as lymphovascular invasion, tumor architecture, multifocality, concomitant CIS, variant histology and biomarker status among others. Based on these variables, several predictive tools have been developed; however, they often lack of validation. The value of these features and tools needs prospective testing. Conclusion: Efforts provided by international collaboration groups have permitted to validate established features and identify new features of biologically and clinically aggressive UTUC. Further investigation on prognostic factors and biomarkers is still needed to assess the benefit of these features and tools on clinical decision-making.

Original languageEnglish (US)
Pages (from-to)337-353
Number of pages17
JournalWorld Journal of Urology
Volume35
Issue number3
DOIs
StatePublished - Mar 1 2017

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Carcinoma
Biomarkers
Biological Factors
Rare Diseases
PubMed
MEDLINE
Neoplasms
Decision Making
Histology
Patient Care
Lymph Nodes
Databases
Guidelines
Neoplasm Metastasis
Recurrence
Survival
Clinical Studies
Clinical Decision-Making

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Mbeutcha, A., Rouprêt, M., Kamat, A. M., Karakiewicz, P. I., Lawrentschuk, N., Novara, G., ... Shariat, S. F. (2017). Prognostic factors and predictive tools for upper tract urothelial carcinoma: a systematic review. World Journal of Urology, 35(3), 337-353. https://doi.org/10.1007/s00345-016-1826-2
Mbeutcha, Aurélie ; Rouprêt, Morgan ; Kamat, Ashish M. ; Karakiewicz, Pierre I. ; Lawrentschuk, Nathan ; Novara, Giacomo ; Raman, Jay ; Seitz, Christian ; Xylinas, Evanguelos ; Shariat, Shahrokh F. / Prognostic factors and predictive tools for upper tract urothelial carcinoma : a systematic review. In: World Journal of Urology. 2017 ; Vol. 35, No. 3. pp. 337-353.
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Mbeutcha, A, Rouprêt, M, Kamat, AM, Karakiewicz, PI, Lawrentschuk, N, Novara, G, Raman, J, Seitz, C, Xylinas, E & Shariat, SF 2017, 'Prognostic factors and predictive tools for upper tract urothelial carcinoma: a systematic review', World Journal of Urology, vol. 35, no. 3, pp. 337-353. https://doi.org/10.1007/s00345-016-1826-2

Prognostic factors and predictive tools for upper tract urothelial carcinoma : a systematic review. / Mbeutcha, Aurélie; Rouprêt, Morgan; Kamat, Ashish M.; Karakiewicz, Pierre I.; Lawrentschuk, Nathan; Novara, Giacomo; Raman, Jay; Seitz, Christian; Xylinas, Evanguelos; Shariat, Shahrokh F.

In: World Journal of Urology, Vol. 35, No. 3, 01.03.2017, p. 337-353.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Prognostic factors and predictive tools for upper tract urothelial carcinoma

T2 - a systematic review

AU - Mbeutcha, Aurélie

AU - Rouprêt, Morgan

AU - Kamat, Ashish M.

AU - Karakiewicz, Pierre I.

AU - Lawrentschuk, Nathan

AU - Novara, Giacomo

AU - Raman, Jay

AU - Seitz, Christian

AU - Xylinas, Evanguelos

AU - Shariat, Shahrokh F.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Background: Upper tract urothelial carcinoma (UTUC) is a rare and heterogeneous disease. Several clinical and biological prognostic factors have been identified in multi-institutional collaborative works with the aim of helping decision-making in pursuit of tailored individual patient care. This review provides an overview of these existing prognostic factors and predictive tools for the management of patients with UTUC. Methods: A systematic literature search was performed using PubMed/MEDLINE, Web of Science and Scopus databases regarding articles published in English between January 2000 and November 2015 according to PRISMA guidelines. Thresholds of 100 and 300 patients were applied for studies on biomarkers and clinical studies, respectively. All the studies on predictive tools were included for analysis. Outcomes of interest were features associated with advanced-stage UTUC, disease recurrence and survival. Results: A total of 116 studies were included in this review. These large and/or multi-institutional studies have confirmed the prognostic value of standard pathological factors (i.e., tumor stage, grade and lymph node metastasis) and identified novel features such as lymphovascular invasion, tumor architecture, multifocality, concomitant CIS, variant histology and biomarker status among others. Based on these variables, several predictive tools have been developed; however, they often lack of validation. The value of these features and tools needs prospective testing. Conclusion: Efforts provided by international collaboration groups have permitted to validate established features and identify new features of biologically and clinically aggressive UTUC. Further investigation on prognostic factors and biomarkers is still needed to assess the benefit of these features and tools on clinical decision-making.

AB - Background: Upper tract urothelial carcinoma (UTUC) is a rare and heterogeneous disease. Several clinical and biological prognostic factors have been identified in multi-institutional collaborative works with the aim of helping decision-making in pursuit of tailored individual patient care. This review provides an overview of these existing prognostic factors and predictive tools for the management of patients with UTUC. Methods: A systematic literature search was performed using PubMed/MEDLINE, Web of Science and Scopus databases regarding articles published in English between January 2000 and November 2015 according to PRISMA guidelines. Thresholds of 100 and 300 patients were applied for studies on biomarkers and clinical studies, respectively. All the studies on predictive tools were included for analysis. Outcomes of interest were features associated with advanced-stage UTUC, disease recurrence and survival. Results: A total of 116 studies were included in this review. These large and/or multi-institutional studies have confirmed the prognostic value of standard pathological factors (i.e., tumor stage, grade and lymph node metastasis) and identified novel features such as lymphovascular invasion, tumor architecture, multifocality, concomitant CIS, variant histology and biomarker status among others. Based on these variables, several predictive tools have been developed; however, they often lack of validation. The value of these features and tools needs prospective testing. Conclusion: Efforts provided by international collaboration groups have permitted to validate established features and identify new features of biologically and clinically aggressive UTUC. Further investigation on prognostic factors and biomarkers is still needed to assess the benefit of these features and tools on clinical decision-making.

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DO - 10.1007/s00345-016-1826-2

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Mbeutcha A, Rouprêt M, Kamat AM, Karakiewicz PI, Lawrentschuk N, Novara G et al. Prognostic factors and predictive tools for upper tract urothelial carcinoma: a systematic review. World Journal of Urology. 2017 Mar 1;35(3):337-353. https://doi.org/10.1007/s00345-016-1826-2