Prognostic factors in malignant melanoma patients with solitary or multiple brain metastases

Is there a role for surgery?

M. M. Konstadoulakis, Evangelos Messaris, G. Zografos, G. Androulakis, C. Karakousis, N. Di Lorenzo, P. Gallina, D. Schiffer

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background. The aim of this study is to evaluate the prognostic parameters and treatment modalities of malignant melanoma patients with brain metastases. Methods. Experimental design: a retrospective study with a mean follow-up of 46 months. Setting: specialized Cancer Center. Patients: the charts of 136 patients, treated in Roswell Park Cancer Institute, for melanoma brain metastases, were analyzed. Interventions: all patients were treated surgically and in the majority adjuvant therapy was applied. Measures: survival and time of recurrence of patients and possible prognostic factors. Results. Patients who were treated surgically had a better one-year survival rate (28.3%), than patients who received radiotherapy and/or chemotherapy (6.67%) or patients who refused any kind of treatment (3.45%), (p=0.006). Prolonged survival after surgical treatment was found in patients with single metastatic lesions and in patients with multiple metastatic lesions. Conclusions. Melanoma patients with single metastatic lesions to the brain seem to do better after surgical treatment. The role of surgical intervention in patients with multiple brain metastases needs re-evaluation from a big multicenter, prospective trial.

Original languageEnglish (US)
Pages (from-to)211-219
Number of pages9
JournalJournal of Neurosurgical Sciences
Volume44
Issue number4
StatePublished - Dec 1 2000

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Melanoma
Neoplasm Metastasis
Brain
Therapeutics
Survival
Multicenter Studies
Neoplasms
Research Design
Radiotherapy
Survival Rate
Retrospective Studies
Recurrence
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

Konstadoulakis, M. M., Messaris, E., Zografos, G., Androulakis, G., Karakousis, C., Di Lorenzo, N., ... Schiffer, D. (2000). Prognostic factors in malignant melanoma patients with solitary or multiple brain metastases: Is there a role for surgery? Journal of Neurosurgical Sciences, 44(4), 211-219.
Konstadoulakis, M. M. ; Messaris, Evangelos ; Zografos, G. ; Androulakis, G. ; Karakousis, C. ; Di Lorenzo, N. ; Gallina, P. ; Schiffer, D. / Prognostic factors in malignant melanoma patients with solitary or multiple brain metastases : Is there a role for surgery?. In: Journal of Neurosurgical Sciences. 2000 ; Vol. 44, No. 4. pp. 211-219.
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abstract = "Background. The aim of this study is to evaluate the prognostic parameters and treatment modalities of malignant melanoma patients with brain metastases. Methods. Experimental design: a retrospective study with a mean follow-up of 46 months. Setting: specialized Cancer Center. Patients: the charts of 136 patients, treated in Roswell Park Cancer Institute, for melanoma brain metastases, were analyzed. Interventions: all patients were treated surgically and in the majority adjuvant therapy was applied. Measures: survival and time of recurrence of patients and possible prognostic factors. Results. Patients who were treated surgically had a better one-year survival rate (28.3{\%}), than patients who received radiotherapy and/or chemotherapy (6.67{\%}) or patients who refused any kind of treatment (3.45{\%}), (p=0.006). Prolonged survival after surgical treatment was found in patients with single metastatic lesions and in patients with multiple metastatic lesions. Conclusions. Melanoma patients with single metastatic lesions to the brain seem to do better after surgical treatment. The role of surgical intervention in patients with multiple brain metastases needs re-evaluation from a big multicenter, prospective trial.",
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Konstadoulakis, MM, Messaris, E, Zografos, G, Androulakis, G, Karakousis, C, Di Lorenzo, N, Gallina, P & Schiffer, D 2000, 'Prognostic factors in malignant melanoma patients with solitary or multiple brain metastases: Is there a role for surgery?', Journal of Neurosurgical Sciences, vol. 44, no. 4, pp. 211-219.

Prognostic factors in malignant melanoma patients with solitary or multiple brain metastases : Is there a role for surgery? / Konstadoulakis, M. M.; Messaris, Evangelos; Zografos, G.; Androulakis, G.; Karakousis, C.; Di Lorenzo, N.; Gallina, P.; Schiffer, D.

In: Journal of Neurosurgical Sciences, Vol. 44, No. 4, 01.12.2000, p. 211-219.

Research output: Contribution to journalArticle

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T1 - Prognostic factors in malignant melanoma patients with solitary or multiple brain metastases

T2 - Is there a role for surgery?

AU - Konstadoulakis, M. M.

AU - Messaris, Evangelos

AU - Zografos, G.

AU - Androulakis, G.

AU - Karakousis, C.

AU - Di Lorenzo, N.

AU - Gallina, P.

AU - Schiffer, D.

PY - 2000/12/1

Y1 - 2000/12/1

N2 - Background. The aim of this study is to evaluate the prognostic parameters and treatment modalities of malignant melanoma patients with brain metastases. Methods. Experimental design: a retrospective study with a mean follow-up of 46 months. Setting: specialized Cancer Center. Patients: the charts of 136 patients, treated in Roswell Park Cancer Institute, for melanoma brain metastases, were analyzed. Interventions: all patients were treated surgically and in the majority adjuvant therapy was applied. Measures: survival and time of recurrence of patients and possible prognostic factors. Results. Patients who were treated surgically had a better one-year survival rate (28.3%), than patients who received radiotherapy and/or chemotherapy (6.67%) or patients who refused any kind of treatment (3.45%), (p=0.006). Prolonged survival after surgical treatment was found in patients with single metastatic lesions and in patients with multiple metastatic lesions. Conclusions. Melanoma patients with single metastatic lesions to the brain seem to do better after surgical treatment. The role of surgical intervention in patients with multiple brain metastases needs re-evaluation from a big multicenter, prospective trial.

AB - Background. The aim of this study is to evaluate the prognostic parameters and treatment modalities of malignant melanoma patients with brain metastases. Methods. Experimental design: a retrospective study with a mean follow-up of 46 months. Setting: specialized Cancer Center. Patients: the charts of 136 patients, treated in Roswell Park Cancer Institute, for melanoma brain metastases, were analyzed. Interventions: all patients were treated surgically and in the majority adjuvant therapy was applied. Measures: survival and time of recurrence of patients and possible prognostic factors. Results. Patients who were treated surgically had a better one-year survival rate (28.3%), than patients who received radiotherapy and/or chemotherapy (6.67%) or patients who refused any kind of treatment (3.45%), (p=0.006). Prolonged survival after surgical treatment was found in patients with single metastatic lesions and in patients with multiple metastatic lesions. Conclusions. Melanoma patients with single metastatic lesions to the brain seem to do better after surgical treatment. The role of surgical intervention in patients with multiple brain metastases needs re-evaluation from a big multicenter, prospective trial.

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Konstadoulakis MM, Messaris E, Zografos G, Androulakis G, Karakousis C, Di Lorenzo N et al. Prognostic factors in malignant melanoma patients with solitary or multiple brain metastases: Is there a role for surgery? Journal of Neurosurgical Sciences. 2000 Dec 1;44(4):211-219.