Prognostic potential of neutrophil-to-lymphocyte ratio and lymphocyte nadir in stage III non-small-cell lung cancer

Kylie H. Kang, Jimmy T. Efird, Neelesh Sharma, Michael Yang, Afshin Dowlati, Philip Linden, Mitchell MacHtay, Tithi Biswas

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Aim: Studies have shown increased pretreatment neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios to be predictive of survival in various cancers. Our aim was to evaluate the prognostic role of such inflammatory markers in non-small-cell lung cancer (NSCLC). Methods: One hundred and sixty-three patients with stage III NSCLC who received definitive treatment were included. Survival analysis was performed using Kaplan-Meier method. Hazard ratios for overall and recurrence-free survival were estimated using Cox proportional hazards model. Results: Both neutrophil-to-lymphocyte >Q75 (4.5) and lymphocyte nadir values <Q25 (0.25) and their unified values were associated with 90% increased overall mortality risk (p = 0.040) and a nonsignificant 50% decreased recurrence-free survival risk. Conclusion: Our exploratory analysis showed markers of systemic inflammation predicted survival outcomes in advanced NSCLC. Future prospective data analyses are needed to confirm this potential.

Original languageEnglish (US)
Article number0045
JournalFuture Oncology
Volume13
Issue number16
DOIs
StatePublished - Jul 2017

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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