Prognostic value of combining a quantitative image feature from positron emission tomography with clinical factors in oligometastatic non-small cell lung cancer

Garrett L. Jensen, Christine M. Yost, Dennis S. Mackin, David V. Fried, Shouhao Zhou, Laurence E. Court, Daniel R. Gomez

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background and purpose: Oligometastatic non-small cell lung cancer (NSCLC) is a heterogeneous condition with few known risk stratification factors. A quantitative imaging feature (QIF) on positron emission tomography (PET), gray-level co-occurrence matrix energy, has been linked with outcome of nonmetastatic NSCLC. We hypothesized that GLCM energy would enhance the ability of models comprising standard clinical prognostic factors (CPFs) to stratify oligometastatic patients based on overall survival (OS). Materials and methods: We assessed 79 patients with oligometastatic NSCLC (≤3 metastases) diagnosed in 2007–2015. The primary and largest metastases at diagnosis were delineated on pretreatment scans with GLCM energy extracted using imaging biomarker explorer (IBEX) software. Iterative stepwise elimination feature selection based on the Akaike information criterion identified the optimal model comprising CPFs for predicting OS in a multivariate Cox proportional hazards model. GLCM energy was tested for improving prediction accuracy. Results: Energy was a significant predictor of OS (P = 0.028) in addition to the selected CPFs. The c-indexes for the CPF-only and CPF + Energy models were 0.720 and 0.739. Conclusions: Incorporating Energy strengthened a CPF model for predicting OS. These findings support further exploration of QIFs, including markers of the primary tumor vs. those of the metastatic sites.

Original languageEnglish (US)
Pages (from-to)362-367
Number of pages6
JournalRadiotherapy and Oncology
Volume126
Issue number2
DOIs
StatePublished - Feb 2018

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Non-Small Cell Lung Carcinoma
Positron-Emission Tomography
Survival
Neoplasm Metastasis
Tumor Biomarkers
Proportional Hazards Models
Software
Biomarkers

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Jensen, Garrett L. ; Yost, Christine M. ; Mackin, Dennis S. ; Fried, David V. ; Zhou, Shouhao ; Court, Laurence E. ; Gomez, Daniel R. / Prognostic value of combining a quantitative image feature from positron emission tomography with clinical factors in oligometastatic non-small cell lung cancer. In: Radiotherapy and Oncology. 2018 ; Vol. 126, No. 2. pp. 362-367.
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Prognostic value of combining a quantitative image feature from positron emission tomography with clinical factors in oligometastatic non-small cell lung cancer. / Jensen, Garrett L.; Yost, Christine M.; Mackin, Dennis S.; Fried, David V.; Zhou, Shouhao; Court, Laurence E.; Gomez, Daniel R.

In: Radiotherapy and Oncology, Vol. 126, No. 2, 02.2018, p. 362-367.

Research output: Contribution to journalArticle

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AU - Jensen, Garrett L.

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AU - Fried, David V.

AU - Zhou, Shouhao

AU - Court, Laurence E.

AU - Gomez, Daniel R.

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