Programmable release of multiple protein drugs from aptamer-functionalized hydrogels via nucleic acid hybridization

Mark R. Battig, Boonchoy Soontornworajit, Yong Wang

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Polymeric delivery systems have been extensively studied to achieve localized and controlled release of protein drugs. However, it is still challenging to control the release of multiple protein drugs in distinct stages according to the progress of disease or treatment. This study successfully demonstrates that multiple protein drugs can be released from aptamer-functionalized hydrogels with adjustable release rates at predetermined time points using complementary sequences (CSs) as biomolecular triggers. Because both aptamer-protein interactions and aptamer-CS hybridization are sequence-specific, aptamer-functionalized hydrogels constitute a promising polymeric delivery system for the programmable release of multiple protein drugs to treat complex human diseases.

Original languageEnglish (US)
Pages (from-to)12410-12413
Number of pages4
JournalJournal of the American Chemical Society
Volume134
Issue number30
DOIs
StatePublished - Aug 1 2012

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Nucleic Acid Hybridization
Hydrogels
Nucleic acids
Nucleic Acids
Proteins
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

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Programmable release of multiple protein drugs from aptamer-functionalized hydrogels via nucleic acid hybridization. / Battig, Mark R.; Soontornworajit, Boonchoy; Wang, Yong.

In: Journal of the American Chemical Society, Vol. 134, No. 30, 01.08.2012, p. 12410-12413.

Research output: Contribution to journalArticle

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