Progress and prospect of mesenchymal stem cell-based therapy in atherosclerosis

Ximei Zhang, Feng Huang, Yanming Chen, Xiaoxian Qian, Song Guo Zheng

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Atherosclerosis is a chronic inflammatory disease of the arterial intima, occurring usually in the aged populations who are suffering from hypertension, dyslipidemia and diabetes for a long time. Research on atherosclerosis has shown that macrophage foam cell formation, inflammation, dyslipidemia and immune cells infiltration are all involved in regulating the onset and progression of atherosclerosis. Mesenchymal stem cells (MSCs) originated from different kinds of tissue are a group of cells possessing well-established self-renewal and multipotent differentiation properties as well as immunomodulatory and anti-inflammatory roles. Recent studies have displayed their dyslipidemia regulation functions. Transplantation of MSCs to atherosclerotic patients might be a new multifactorial therapeutic strategy to improve atherosclerosis. This review updates the advancement on MSCs and atherosclerosis.

Original languageEnglish (US)
Article numberAJTR0037131
Pages (from-to)4017-4024
Number of pages8
JournalAmerican Journal of Translational Research
Volume8
Issue number10
StatePublished - Oct 30 2016

Fingerprint

Cell- and Tissue-Based Therapy
Stem cells
Mesenchymal Stromal Cells
Atherosclerosis
Dyslipidemias
Macrophages
Medical problems
Infiltration
Foams
Mesenchymal Stem Cell Transplantation
Tunica Intima
Anti-Inflammatory Agents
Foam Cells
Tissue
Chronic Disease
Hypertension
Inflammation
Research
Population
Therapeutics

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Clinical Biochemistry
  • Cancer Research

Cite this

Zhang, X., Huang, F., Chen, Y., Qian, X., & Zheng, S. G. (2016). Progress and prospect of mesenchymal stem cell-based therapy in atherosclerosis. American Journal of Translational Research, 8(10), 4017-4024. [AJTR0037131].
Zhang, Ximei ; Huang, Feng ; Chen, Yanming ; Qian, Xiaoxian ; Zheng, Song Guo. / Progress and prospect of mesenchymal stem cell-based therapy in atherosclerosis. In: American Journal of Translational Research. 2016 ; Vol. 8, No. 10. pp. 4017-4024.
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Zhang, X, Huang, F, Chen, Y, Qian, X & Zheng, SG 2016, 'Progress and prospect of mesenchymal stem cell-based therapy in atherosclerosis', American Journal of Translational Research, vol. 8, no. 10, AJTR0037131, pp. 4017-4024.

Progress and prospect of mesenchymal stem cell-based therapy in atherosclerosis. / Zhang, Ximei; Huang, Feng; Chen, Yanming; Qian, Xiaoxian; Zheng, Song Guo.

In: American Journal of Translational Research, Vol. 8, No. 10, AJTR0037131, 30.10.2016, p. 4017-4024.

Research output: Contribution to journalReview article

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AB - Atherosclerosis is a chronic inflammatory disease of the arterial intima, occurring usually in the aged populations who are suffering from hypertension, dyslipidemia and diabetes for a long time. Research on atherosclerosis has shown that macrophage foam cell formation, inflammation, dyslipidemia and immune cells infiltration are all involved in regulating the onset and progression of atherosclerosis. Mesenchymal stem cells (MSCs) originated from different kinds of tissue are a group of cells possessing well-established self-renewal and multipotent differentiation properties as well as immunomodulatory and anti-inflammatory roles. Recent studies have displayed their dyslipidemia regulation functions. Transplantation of MSCs to atherosclerotic patients might be a new multifactorial therapeutic strategy to improve atherosclerosis. This review updates the advancement on MSCs and atherosclerosis.

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Zhang X, Huang F, Chen Y, Qian X, Zheng SG. Progress and prospect of mesenchymal stem cell-based therapy in atherosclerosis. American Journal of Translational Research. 2016 Oct 30;8(10):4017-4024. AJTR0037131.