Progress towards a multi-modal capsule endoscopy device featuring microultrasound imaging

H. S. Lay, Y. Qiu, M. Al-Rawhani, J. Beeley, R. Poltarjonoks, V. Seetohul, D. Cumming, S. Cochran, G. Cummins, M. P.Y. Desmulliez, M. Wallace, S. Trolier-McKinstry, R. McPhillips, B. F. Cox, C. E.M. Demore

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

Current clinical standards for endoscopy in the gastrointestinal (GI) tract combine high definition optics and ultrasound imaging to view the lumen superficially and through its thickness. However, these instruments are limited to the length of an endoscope and the only clinically available, autonomous devices able to travel the full length of the GI tract easily offer only video capsule endoscopy (VCE). Our work seeks to overcome this limitation with a device ('Sonopill') for multimodal capsule endoscopy, providing optical and microultrasound (μUS) imaging and supporting sensors1. μUS transducers have been developed with multiple piezoelectric materials operating across a range of centre frequencies to study viability in the GI tract. Because of the combined constraints of μUS imaging and the low power / heat tolerance of autonomous devices, a hybrid approach has been taken to the transducer design, with separate transmit and receive arrays allowing multiple manufacturing approaches to maximise system efficiency. To explore these approaches fully, prototype devices have been developed with PVDF, highfrequency PZT and PMN-PT composites, and piezoelectric micromachined ultrasonic transducer arrays. Test capsules have been developed using 3D printing to investigate issues including power consumption, heat generation / dissipation, acoustic coupling, signal strength and capsule integrity. Because of the high functional density of the electronics in our proposed system, application specific integrated circuits (ASICs) have been developed to realise the ultrasound transmit and receive circuitry along with white-light and autofluorescence imaging with singlephoton avalanche detectors (SPADs). The ultrasound ASIC has been developed and the SPAD electronics and optical subsystem have been validated experimentally. The functionality of various transducer materials has been examined as a function of frequency and ultrasound transducers have been developed to operate at centre frequencies in the range 15 - 50 MHz. Ex vivo testing of porcine tissue has been performed, generating images of interest to the clinical community, demonstrating the viability of the Sonopill concept.

Original languageEnglish (US)
Title of host publication2016 IEEE International Ultrasonics Symposium, IUS 2016
PublisherIEEE Computer Society
ISBN (Electronic)9781467398978
DOIs
StatePublished - Nov 1 2016
Event2016 IEEE International Ultrasonics Symposium, IUS 2016 - Tours, France
Duration: Sep 18 2016Sep 21 2016

Publication series

NameIEEE International Ultrasonics Symposium, IUS
Volume2016-November
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Other

Other2016 IEEE International Ultrasonics Symposium, IUS 2016
CountryFrance
CityTours
Period9/18/169/21/16

Fingerprint

capsules
transducers
application specific integrated circuits
viability
avalanches
heat tolerance
acoustic coupling
endoscopes
lumens
heat generation
detectors
electronics
printing
integrity
travel
dissipation
manufacturing
ultrasonics
prototypes
optics

All Science Journal Classification (ASJC) codes

  • Acoustics and Ultrasonics

Cite this

Lay, H. S., Qiu, Y., Al-Rawhani, M., Beeley, J., Poltarjonoks, R., Seetohul, V., ... Demore, C. E. M. (2016). Progress towards a multi-modal capsule endoscopy device featuring microultrasound imaging. In 2016 IEEE International Ultrasonics Symposium, IUS 2016 [7728692] (IEEE International Ultrasonics Symposium, IUS; Vol. 2016-November). IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2016.7728692
Lay, H. S. ; Qiu, Y. ; Al-Rawhani, M. ; Beeley, J. ; Poltarjonoks, R. ; Seetohul, V. ; Cumming, D. ; Cochran, S. ; Cummins, G. ; Desmulliez, M. P.Y. ; Wallace, M. ; Trolier-McKinstry, S. ; McPhillips, R. ; Cox, B. F. ; Demore, C. E.M. / Progress towards a multi-modal capsule endoscopy device featuring microultrasound imaging. 2016 IEEE International Ultrasonics Symposium, IUS 2016. IEEE Computer Society, 2016. (IEEE International Ultrasonics Symposium, IUS).
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abstract = "Current clinical standards for endoscopy in the gastrointestinal (GI) tract combine high definition optics and ultrasound imaging to view the lumen superficially and through its thickness. However, these instruments are limited to the length of an endoscope and the only clinically available, autonomous devices able to travel the full length of the GI tract easily offer only video capsule endoscopy (VCE). Our work seeks to overcome this limitation with a device ('Sonopill') for multimodal capsule endoscopy, providing optical and microultrasound (μUS) imaging and supporting sensors1. μUS transducers have been developed with multiple piezoelectric materials operating across a range of centre frequencies to study viability in the GI tract. Because of the combined constraints of μUS imaging and the low power / heat tolerance of autonomous devices, a hybrid approach has been taken to the transducer design, with separate transmit and receive arrays allowing multiple manufacturing approaches to maximise system efficiency. To explore these approaches fully, prototype devices have been developed with PVDF, highfrequency PZT and PMN-PT composites, and piezoelectric micromachined ultrasonic transducer arrays. Test capsules have been developed using 3D printing to investigate issues including power consumption, heat generation / dissipation, acoustic coupling, signal strength and capsule integrity. Because of the high functional density of the electronics in our proposed system, application specific integrated circuits (ASICs) have been developed to realise the ultrasound transmit and receive circuitry along with white-light and autofluorescence imaging with singlephoton avalanche detectors (SPADs). The ultrasound ASIC has been developed and the SPAD electronics and optical subsystem have been validated experimentally. The functionality of various transducer materials has been examined as a function of frequency and ultrasound transducers have been developed to operate at centre frequencies in the range 15 - 50 MHz. Ex vivo testing of porcine tissue has been performed, generating images of interest to the clinical community, demonstrating the viability of the Sonopill concept.",
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Lay, HS, Qiu, Y, Al-Rawhani, M, Beeley, J, Poltarjonoks, R, Seetohul, V, Cumming, D, Cochran, S, Cummins, G, Desmulliez, MPY, Wallace, M, Trolier-McKinstry, S, McPhillips, R, Cox, BF & Demore, CEM 2016, Progress towards a multi-modal capsule endoscopy device featuring microultrasound imaging. in 2016 IEEE International Ultrasonics Symposium, IUS 2016., 7728692, IEEE International Ultrasonics Symposium, IUS, vol. 2016-November, IEEE Computer Society, 2016 IEEE International Ultrasonics Symposium, IUS 2016, Tours, France, 9/18/16. https://doi.org/10.1109/ULTSYM.2016.7728692

Progress towards a multi-modal capsule endoscopy device featuring microultrasound imaging. / Lay, H. S.; Qiu, Y.; Al-Rawhani, M.; Beeley, J.; Poltarjonoks, R.; Seetohul, V.; Cumming, D.; Cochran, S.; Cummins, G.; Desmulliez, M. P.Y.; Wallace, M.; Trolier-McKinstry, S.; McPhillips, R.; Cox, B. F.; Demore, C. E.M.

2016 IEEE International Ultrasonics Symposium, IUS 2016. IEEE Computer Society, 2016. 7728692 (IEEE International Ultrasonics Symposium, IUS; Vol. 2016-November).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Lay HS, Qiu Y, Al-Rawhani M, Beeley J, Poltarjonoks R, Seetohul V et al. Progress towards a multi-modal capsule endoscopy device featuring microultrasound imaging. In 2016 IEEE International Ultrasonics Symposium, IUS 2016. IEEE Computer Society. 2016. 7728692. (IEEE International Ultrasonics Symposium, IUS). https://doi.org/10.1109/ULTSYM.2016.7728692