Progressive brain structural changes after the first year of treatment in first-episode treatment-naive patients with deficit or nondeficit schizophrenia

Wei Lei, Brian Kirkpatrick, Qiang Wang, Wei Deng, Mingli Li, Wanjun Guo, Sugai Liang, Yinfei Li, Chengcheng Zhang, Xiaojing Li, Pingping Zhang, Zhe Li, Bo Xiang, Jing Chen, Xun Hu, Nanyin Zhang, Tao Li

Research output: Contribution to journalArticle

Abstract

Progressive brain volume atrophy has been reported in patients with schizophrenia. However, whether this progress differs between patients with primary negative symptoms (deficit schizophrenia; DS) and those without such symptoms (nondeficit schizophrenia; NDS) is unknown. Here, we examined grey matter volume (GMV) and white matter volume (WMV) changes over 12 months in 34 first-episode treatment-naive patients with schizophrenia (14 DS and 20 NDS) and 32 healthy controls (HCs) using structural magnetic resonance imaging and voxel-based morphometry. At baseline, compared to HCs, patients with DS but not NDS had less WMV in bilateral posterior limb of the internal capsule (PLIC) and cerebellar tonsil (P < 0.05, FDR corrected) and smaller GMV in the cerebellar culmen (P < 0.05, FWE corrected). At follow-up, NDS group showed WMV reduction in bilateral PLIC (P < 0.05, FDR corrected), while DS group showed no progressive WMV changes. While both patient groups exhibited GMV reduction in the hippocampus and insular cortex, patients with NDS showed additional GMV loss in the frontal and cingulate cortex and a selective increase in GMV in the left thalamus (P < 0.05 FWE corrected). Our study revealed double dissociations in developmental brain volume changes in the first year after clinical contact for psychosis in DS versus NDS patients.

Original languageEnglish (US)
Pages (from-to)12-20
Number of pages9
JournalPsychiatry Research - Neuroimaging
Volume288
DOIs
StatePublished - Jun 30 2019

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Schizophrenia
Brain
Internal Capsule
Therapeutics
Extremities
Palatine Tonsil
Gyrus Cinguli
Frontal Lobe
Thalamus
Cerebral Cortex
Psychotic Disorders
Atrophy
diazonaphthalenedisulfonic acid
Hippocampus
Magnetic Resonance Imaging
Gray Matter
White Matter

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

Cite this

Lei, Wei ; Kirkpatrick, Brian ; Wang, Qiang ; Deng, Wei ; Li, Mingli ; Guo, Wanjun ; Liang, Sugai ; Li, Yinfei ; Zhang, Chengcheng ; Li, Xiaojing ; Zhang, Pingping ; Li, Zhe ; Xiang, Bo ; Chen, Jing ; Hu, Xun ; Zhang, Nanyin ; Li, Tao. / Progressive brain structural changes after the first year of treatment in first-episode treatment-naive patients with deficit or nondeficit schizophrenia. In: Psychiatry Research - Neuroimaging. 2019 ; Vol. 288. pp. 12-20.
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abstract = "Progressive brain volume atrophy has been reported in patients with schizophrenia. However, whether this progress differs between patients with primary negative symptoms (deficit schizophrenia; DS) and those without such symptoms (nondeficit schizophrenia; NDS) is unknown. Here, we examined grey matter volume (GMV) and white matter volume (WMV) changes over 12 months in 34 first-episode treatment-naive patients with schizophrenia (14 DS and 20 NDS) and 32 healthy controls (HCs) using structural magnetic resonance imaging and voxel-based morphometry. At baseline, compared to HCs, patients with DS but not NDS had less WMV in bilateral posterior limb of the internal capsule (PLIC) and cerebellar tonsil (P < 0.05, FDR corrected) and smaller GMV in the cerebellar culmen (P < 0.05, FWE corrected). At follow-up, NDS group showed WMV reduction in bilateral PLIC (P < 0.05, FDR corrected), while DS group showed no progressive WMV changes. While both patient groups exhibited GMV reduction in the hippocampus and insular cortex, patients with NDS showed additional GMV loss in the frontal and cingulate cortex and a selective increase in GMV in the left thalamus (P < 0.05 FWE corrected). Our study revealed double dissociations in developmental brain volume changes in the first year after clinical contact for psychosis in DS versus NDS patients.",
author = "Wei Lei and Brian Kirkpatrick and Qiang Wang and Wei Deng and Mingli Li and Wanjun Guo and Sugai Liang and Yinfei Li and Chengcheng Zhang and Xiaojing Li and Pingping Zhang and Zhe Li and Bo Xiang and Jing Chen and Xun Hu and Nanyin Zhang and Tao Li",
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Lei, W, Kirkpatrick, B, Wang, Q, Deng, W, Li, M, Guo, W, Liang, S, Li, Y, Zhang, C, Li, X, Zhang, P, Li, Z, Xiang, B, Chen, J, Hu, X, Zhang, N & Li, T 2019, 'Progressive brain structural changes after the first year of treatment in first-episode treatment-naive patients with deficit or nondeficit schizophrenia', Psychiatry Research - Neuroimaging, vol. 288, pp. 12-20. https://doi.org/10.1016/j.pscychresns.2019.04.009

Progressive brain structural changes after the first year of treatment in first-episode treatment-naive patients with deficit or nondeficit schizophrenia. / Lei, Wei; Kirkpatrick, Brian; Wang, Qiang; Deng, Wei; Li, Mingli; Guo, Wanjun; Liang, Sugai; Li, Yinfei; Zhang, Chengcheng; Li, Xiaojing; Zhang, Pingping; Li, Zhe; Xiang, Bo; Chen, Jing; Hu, Xun; Zhang, Nanyin; Li, Tao.

In: Psychiatry Research - Neuroimaging, Vol. 288, 30.06.2019, p. 12-20.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Progressive brain structural changes after the first year of treatment in first-episode treatment-naive patients with deficit or nondeficit schizophrenia

AU - Lei, Wei

AU - Kirkpatrick, Brian

AU - Wang, Qiang

AU - Deng, Wei

AU - Li, Mingli

AU - Guo, Wanjun

AU - Liang, Sugai

AU - Li, Yinfei

AU - Zhang, Chengcheng

AU - Li, Xiaojing

AU - Zhang, Pingping

AU - Li, Zhe

AU - Xiang, Bo

AU - Chen, Jing

AU - Hu, Xun

AU - Zhang, Nanyin

AU - Li, Tao

PY - 2019/6/30

Y1 - 2019/6/30

N2 - Progressive brain volume atrophy has been reported in patients with schizophrenia. However, whether this progress differs between patients with primary negative symptoms (deficit schizophrenia; DS) and those without such symptoms (nondeficit schizophrenia; NDS) is unknown. Here, we examined grey matter volume (GMV) and white matter volume (WMV) changes over 12 months in 34 first-episode treatment-naive patients with schizophrenia (14 DS and 20 NDS) and 32 healthy controls (HCs) using structural magnetic resonance imaging and voxel-based morphometry. At baseline, compared to HCs, patients with DS but not NDS had less WMV in bilateral posterior limb of the internal capsule (PLIC) and cerebellar tonsil (P < 0.05, FDR corrected) and smaller GMV in the cerebellar culmen (P < 0.05, FWE corrected). At follow-up, NDS group showed WMV reduction in bilateral PLIC (P < 0.05, FDR corrected), while DS group showed no progressive WMV changes. While both patient groups exhibited GMV reduction in the hippocampus and insular cortex, patients with NDS showed additional GMV loss in the frontal and cingulate cortex and a selective increase in GMV in the left thalamus (P < 0.05 FWE corrected). Our study revealed double dissociations in developmental brain volume changes in the first year after clinical contact for psychosis in DS versus NDS patients.

AB - Progressive brain volume atrophy has been reported in patients with schizophrenia. However, whether this progress differs between patients with primary negative symptoms (deficit schizophrenia; DS) and those without such symptoms (nondeficit schizophrenia; NDS) is unknown. Here, we examined grey matter volume (GMV) and white matter volume (WMV) changes over 12 months in 34 first-episode treatment-naive patients with schizophrenia (14 DS and 20 NDS) and 32 healthy controls (HCs) using structural magnetic resonance imaging and voxel-based morphometry. At baseline, compared to HCs, patients with DS but not NDS had less WMV in bilateral posterior limb of the internal capsule (PLIC) and cerebellar tonsil (P < 0.05, FDR corrected) and smaller GMV in the cerebellar culmen (P < 0.05, FWE corrected). At follow-up, NDS group showed WMV reduction in bilateral PLIC (P < 0.05, FDR corrected), while DS group showed no progressive WMV changes. While both patient groups exhibited GMV reduction in the hippocampus and insular cortex, patients with NDS showed additional GMV loss in the frontal and cingulate cortex and a selective increase in GMV in the left thalamus (P < 0.05 FWE corrected). Our study revealed double dissociations in developmental brain volume changes in the first year after clinical contact for psychosis in DS versus NDS patients.

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