Prolonged Bleeding Times and Bleeding Diathesis Associated With Moxalactam Administration

Michael R. Weitekamp; Robert C. Aber

doi:10.1001/jama.1983.03330250049027

Prolonged Bleeding Times and Bleeding Diathesis Associated With Moxalactam Administration

Michael R. Weitekamp, Robert C. Aber

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Abstract

A reversible bleeding diathesis associated with marked prolongation of the bleeding time was recognized in five patients receiving the new antibiotic moxalactam disodium (Moxam). Platelet dysfunction secondary to interference with adenosine diphosphate-induced aggregation has been demonstrated in vitro. Clinically important hemorrhage consequent to the use of this antibiotic may be more common than previously thought.

Original language	English (US)
Pages (from-to)	69-71
Number of pages	3
Journal	JAMA: The Journal of the American Medical Association
Volume	249
Issue number	1
DOIs	https://doi.org/10.1001/jama.1983.03330250049027
State	Published - Jan 7 1983

All Science Journal Classification (ASJC) codes

Medicine(all)

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10.1001/jama.1983.03330250049027

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abstract = "A reversible bleeding diathesis associated with marked prolongation of the bleeding time was recognized in five patients receiving the new antibiotic moxalactam disodium (Moxam). Platelet dysfunction secondary to interference with adenosine diphosphate-induced aggregation has been demonstrated in vitro. Clinically important hemorrhage consequent to the use of this antibiotic may be more common than previously thought.",

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AB - A reversible bleeding diathesis associated with marked prolongation of the bleeding time was recognized in five patients receiving the new antibiotic moxalactam disodium (Moxam). Platelet dysfunction secondary to interference with adenosine diphosphate-induced aggregation has been demonstrated in vitro. Clinically important hemorrhage consequent to the use of this antibiotic may be more common than previously thought.

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Prolonged Bleeding Times and Bleeding Diathesis Associated With Moxalactam Administration

Abstract

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