Prolonged survival of scavenger receptor class A-deficient mice from pulmonary Mycobacterium tuberculosis infection

Zvjezdana Sever-Chroneos, Amy Tvinnereim, Robert L. Hunter, Zissis Chroneos

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The present study tested the hypothesis that the scavenger receptor SR-A modulates granuloma formation in response to pulmonary infection with Mycobacterium tuberculosis (MTB). To test this hypothesis, we monitored survival and histopathology in WT and SR-A-deficient mice following aerosol infection with MTB Rv. SR-A-deficient (SR-A-/-) mice infected with MTB survived significantly longer than WT mice; the mean survival of SR-A-/- mice exceeded 430 days compared to 230 days for WT mice. Early granuloma formation was not impaired in SR-A-/- mice. The extended survival of SR-A-/- mice was associated with 13- and 3-fold higher number of CD4+ lymphocytes and antigen presenting cells in SR-A-/- lungs compared to WT mice 280 after infection. The histopathology of chronically infected SR-A-/- lungs, however, was marked by abundant cholesterol clefts in parenchymal lesions containing infection in multinucleated giant cells. The present study indicates SR-A as a candidate gene of the innate immune system influencing the chronic phase of M. tuberculosis infection.

Original languageEnglish (US)
JournalTuberculosis
Volume91
Issue numberSUPPL. 1
DOIs
StatePublished - Dec 1 2011

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Class A Scavenger Receptors
Mycobacterium Infections
Pulmonary Tuberculosis
Mycobacterium tuberculosis
Infection
Granuloma
Lung
Scavenger Receptors
CD4 Antigens
Lymphocyte Count
Antigen-Presenting Cells
Giant Cells
Aerosols
Immune System
Cholesterol

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Sever-Chroneos, Zvjezdana ; Tvinnereim, Amy ; Hunter, Robert L. ; Chroneos, Zissis. / Prolonged survival of scavenger receptor class A-deficient mice from pulmonary Mycobacterium tuberculosis infection. In: Tuberculosis. 2011 ; Vol. 91, No. SUPPL. 1.
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Prolonged survival of scavenger receptor class A-deficient mice from pulmonary Mycobacterium tuberculosis infection. / Sever-Chroneos, Zvjezdana; Tvinnereim, Amy; Hunter, Robert L.; Chroneos, Zissis.

In: Tuberculosis, Vol. 91, No. SUPPL. 1, 01.12.2011.

Research output: Contribution to journalArticle

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