TY - JOUR
T1 - Promotion of dendritic growth by CPG15, an activity-induced signaling molecule
AU - Nedivi, Elly
AU - Wu, Gang Yi
AU - Cline, Hollis T.
PY - 1998/9/18
Y1 - 1998/9/18
N2 - Activity-independent and activity-dependent mechanisms work in concert to regulate neuronal growth, ensuring the formation of accurate synaptic connections. CPG15, a protein regulated by synaptic activity, functions as a cell-surface growth-promoting molecule in vivo. In Xenopus laevis, CPG15 enhanced dendritic arbor growth in projection neurons, with no effect on interneurons. CPG15 controlled growth of neighboring neurons through an intercellular signaling mechanism that requires its glycosylphosphatidylinositol link. CPG15 may represent a new class of activity-regulated, membrane-bound, growth-promoting proteins that permit exquisite spatial and temporal control of neuronal structure.
AB - Activity-independent and activity-dependent mechanisms work in concert to regulate neuronal growth, ensuring the formation of accurate synaptic connections. CPG15, a protein regulated by synaptic activity, functions as a cell-surface growth-promoting molecule in vivo. In Xenopus laevis, CPG15 enhanced dendritic arbor growth in projection neurons, with no effect on interneurons. CPG15 controlled growth of neighboring neurons through an intercellular signaling mechanism that requires its glycosylphosphatidylinositol link. CPG15 may represent a new class of activity-regulated, membrane-bound, growth-promoting proteins that permit exquisite spatial and temporal control of neuronal structure.
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U2 - 10.1126/science.281.5384.1863
DO - 10.1126/science.281.5384.1863
M3 - Article
C2 - 9743502
AN - SCOPUS:0032544299
SN - 0036-8075
VL - 281
SP - 1863
EP - 1866
JO - Science
JF - Science
IS - 5384
ER -